Evidence map›Paper›PMID 35667693›Full record

ArticleBMJ case reports2022

Giant cell myositis associated with metastatic thymoma and granulomatous hypercalcaemia.

Jessica C Jimenez, Calixto-Hope G Lucas, Sara C LaHue, Bradley A Sharpe

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jessica C JimenezDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, California, USA.ORCID http://orcid.org/0000-0001-7878-1618
Calixto-Hope G LucasDepartment of Pathology, University of California San Francisco, San Francisco, California, USA.ORCID http://orcid.org/0000-0002-8347-9592
Sara C LaHueDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, California, USA.
Bradley A SharpeDepartment of Medicine, University of California San Francisco, San Francisco, California, USA bradley.sharpe@ucsf.edu.ORCID http://orcid.org/0000-0003-0227-6038
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Giant cell myositis (GCM) is a rare inflammatory myopathy associated with myasthenia gravis and thymoma. Here, we report on a woman in her late 50s with a history of myasthenia gravis, systemic lupus erythematosus and stage IV thymoma with pleural metastases, who presented with proximal weakness, neuromuscular respiratory failure and hypercalcaemia. She was diagnosed with GCM via muscle biopsy and screened for myocarditis but showed no evidence of myocardial involvement. Her hypercalcaemia was consistent with a granulomatous process, likely driven by her GCM. Her strength gradually improved, and her hypercalcaemia did not recur after treatment with high dose steroids, intravenous immune globulin and plasma exchange. Her course was complicated by several opportunistic infections in the setting of her immunosuppression. Despite the high morbidity associated with GCM, she demonstrated clinical improvement after initiating immunosuppressive therapy and continues to be managed in the outpatient setting.

Indexed as

HypercalcemiaMyasthenia GravisMyositisThymomaThymus NeoplasmsFemaleGiant CellsHumansNeoplasm Recurrence, LocalCalcium and boneMuscle diseaseMusculoskeletal syndromesNeuromuscular diseasePathology

Identifiers

PMID35667693
PMCPMC9171203
OpenAlexW4281706181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.