Evidence map›Paper›PMID 35667479›Full record

ArticleBiological psychology2022

Pregnancy anxiety, placental corticotropin-releasing hormone and length of gestation.

Isabel F Ramos, Kharah M Ross, Gabrielle R Rinne, Jennifer A Somers, Roberta A Mancuso, Calvin J Hobel, Mary Coussons-Read, Christine Dunkel Schetter

Open access · hybridFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Isabel F RamosUniversity of California, Irvine, USA. Electronic address: iframos@uci.edu.
Kharah M RossAthabasca University, Athabasca, Alberta, Canada.
Gabrielle R RinneUniversity of California, Los Angeles, USA.
Jennifer A SomersUniversity of California, Los Angeles, USA.
Roberta A MancusoRegis University, USA.
Calvin J HobelCedars-Sinai Medical Center, Los Angeles, USA.
Mary Coussons-ReadUniversity of Colorado, Colorado Springs, USA.
Christine Dunkel SchetterUniversity of California, Los Angeles, USA.
University of California, Los Angeles · USAthabasca University · CACedars-Sinai Medical Center · USRegis University · USUniversity of California, Irvine · USUniversity of Colorado Colorado Springs · US

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Mechanisms & Effects of Prenatal Maternal Affect on Pregnancy & Infant DevelopmentR01HD073491 · NICHD · UNIVERSITY OF COLORADO · PI COUSSONS-READ, MARY E, DUNKEL SCHETTER, CHRISTINE · 2013 to 2017
$3.1M
Biological Mechanisms Related to Pregnancy Anxiety and Prenatal DepressionR03HD096170 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNKEL SCHETTER, CHRISTINE · 2018 to 2018
$75k
NICHD NIH HHS R01 HD073491NICHD NIH HHS R03 HD096170NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

objectiveHigh pregnancy anxiety is a consistent predictor of earlier labor and delivery. Placental corticotropin-releasing hormone (pCRH) predicts earlier delivery consistently and it has been identified as a biological mediator of the association between pregnancy anxiety and gestational length. However, studies have not examined whether changes in pregnancy anxiety are associated with earlier birth as mediated by changes in pCRH during pregnancy. Accordingly, this study tests whether linear changes in pregnancy anxiety are associated with length of gestation indirectly through nonlinear increases in pCRH over pregnancy.

methodsA sample of pregnant women (n=233) completed prenatal assessments in early pregnancy, second trimester, and third trimester that included a 4-item assessment of pregnancy anxiety and collection of blood samples assayed for pCRH using radioimmunoassay. Length of gestation was abstracted from medical records after birth.

resultsIncreases in pregnancy anxiety from early pregnancy to third trimester predicted shorted length of gestation, as did nonlinear increases in pCRH over pregnancy. However, there was no evidence of an indirect effect of changes in pregnancy anxiety on length of gestation via changes in pCRH.

conclusionsThese results indicate that linear changes in pregnancy anxiety and nonlinear changes in pCRH during pregnancy are independent risk factors for shortened gestational length. This study adds to a small but growing body of work on biopsychological processes in pregnancy and length of gestation. Modeling changes in psychological and biological processes during pregnancy could provide more insight into understanding risk for adverse pregnancy outcomes.

Indexed as

Corticotropin-Releasing HormonePlacentaAnxietyAnxiety DisordersFemaleHumansPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdCorticotropin-Releasing HormoneHPA-axisLength of gestationPlacental corticotrophin releasing hormonePregnancy anxietyPreterm birth

Identifiers

PMID35667479
PMCPMC10022399
OpenAlexW4281709799

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read7
measurements read46
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.