ArticleInternational journal of biological macromolecules2022
Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications.
Article in International journal of biological macromolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 89 citations in OpenAlex.
- Enhancing Antimicrobial Efficacy: The Role of Metal Complexation in Chitosan-Based Antimicrobial Agents.Applied biochemistry and biotechnology · 2026Review
- Bladder adaptive hydrogel scaffold with dual release, antimicrobial, immunomodulatory, and repair: DRIVER for urinary tract infections.Acta pharmaceutica Sinica. B · 2026Article
- Enhancing the Antimicrobial Efficacy of CTS Through Complexation and Nanoengineering with Zn: Emerging Trends (2018-2025).Applied biochemistry and biotechnology · 2026Review
- Development of a new biological dressing: the modified cross-linking of Chitosan derived from cuttlefish (Sepia pharaonis) by-products as an effective agent for promoting cell migration.Bioresources and bioprocessing · 2026Article
- Therapeutic Potential of Chitosan-Based and Related Nanocomposite Systems in Wound Management: A Review.International journal of molecular sciences · 2025Review
- Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing.Bioactive materials · 2025Article
- Article
- Chitosan/Bioactive Glass Microparticles Enriched with Therapeutic Metal Ions for Bone Tissue Engineering.ACS applied bio materials · 2025Article
- Nanotopographical Features of Polymeric Nanocomposite Scaffolds for Tissue Engineering and Regenerative Medicine: A Review.Biomimetics (Basel, Switzerland) · 2025Review
- Synergic effect and biosafety of chitosan/zinc complex nanoparticle-based carboxymethyl cellulose coatings for postharvest strawberry preservation.RSC advances · 2025Article
- Zinc Peroxide-Mediated In Situ Forming Hydrogels for Endogenous Tissue Regeneration.Biomaterials research · 2025Article
- Mapping Biomaterial Complexity by Machine Learning.Tissue engineering. Part A · 2024Review
- Preparation of an injectable zinc-containing hydrogel with double dynamic bond and its potential application in the treatment of periodontitis.RSC advances · 2024Article
- Enhanced antibacterial activity of porous chitosan-based hydrogels crosslinked with gelatin and metal ions.Scientific reports · 2024Article
- Bioactive Porous Composite Implant Guides Mesenchymal Stem Cell Differentiation and Migration to Accelerate Bone Reconstruction.International journal of nanomedicine · 2024Article
- Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Review
- Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and ZnInternational journal of molecular sciences · 2023Article
- Antimicrobially Active Zn(II) Complexes of Reduced Schiff Bases Derived from Cyclohexane-1,2-diamine and Fluorinated Benzaldehydes-Synthesis, Crystal Structure and Bioactivity.Life (Basel, Switzerland) · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the successful preparation and characterization of chitosan-Zn complex (ChiZn) in the form of films, intended to enhance the biological performance of chitosan by the presence of Zn as antibacterial agent and biologically active ion. The influence of Zn chelation on morphology and structure of chitosan was assessed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and infrared spectroscopy. The biodegradability study of ChiZn showed a sustained release of Zn up to 2 mg/mL. No toxic response was observed toward stromal cell line ST-2 in indirect contact with the ChiZn films. The dissolution product of ChiZn showed improved wound closure (88% closure) compared to the positive control group (70% closure). Moreover, ChiZn exhibited antibacterial activity against S. aureus together with a slight increase (~30%) in the secretion of VEGF and moderate decrease in nitric oxide evolution. Our findings indicate that ChiZn could be used as a safe and effective wound healing agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.