Evidence map›Paper›PMID 35667407›Full record

ArticleGastroenterology2022

Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice.

Alexandra Demcsák, Miklós Sahin-Tóth

Abstract read
In one paragraph

Article in Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Reevaluating the role of TRPV6 deficiency in human and mouse pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  2. Role of cathepsin B in spontaneous pancreatitis in T7D23A trypsinogen mutant mice.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2026
    Article
  3. Article
  4. Pathologically relevant trypsinogen activation in pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  12. Review
  13. Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandra DemcsákDepartment of Surgery, University of California-Los Angeles, Los Angeles, California.
Miklós Sahin-TóthDepartment of Surgery, University of California-Los Angeles, Los Angeles, California. Electronic address: msahintoth@mednet.ucla.edu.

Funding

Chymotrypsin in pancreatitisR01DK082412 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2009 to 2024
$5.8M
Molecular Pathomechanism of Hereditary PancreatitisR01DK058088 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2001 to 2019
$5.3M
Trypsin-dependent mechanisms in pancreatitisR01DK117809 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2018 to 2022
$2.5M
NIDDK NIH HHS R01 DK058088NIDDK NIH HHS R01 DK082412NIDDK NIH HHS R01 DK117809
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PancreatitisTrypsinogenAnimalsChymotrypsinMicePhenotypeTrypsinChymotrypsinTrypsinTrypsinogen

Identifiers

PMID35667407
PMCPMC9398983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.