Evidence map›Paper›PMID 35667335›Full record

ArticleJournal of psychiatric research2022

Long term outcomes of pediatric Bipolar-I disorder: A prospective follow-up analysis attending to full syndomatic, subsyndromal and functional types of remission.

Janet Wozniak, Maura DiSalvo, Abigail Farrell, Gagan Joshi, Mai Uchida, Stephen V Faraone, Emmaline Cook, Joseph Biederman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Janet WozniakClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: jwozniak@partners.org.
Maura DiSalvoClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Abigail FarrellClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Gagan JoshiClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Mai UchidaClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Stephen V FaraoneDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Emmaline CookClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Joseph BiedermanClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Funding

Discoveries in ADHD genomics: Help or hype in clinical settings?R01MH116037 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOYLE, ALYSA E · 2019 to 2023
$4.4M
Longitudinal Family Study of Pediatric Bipolar DisorderR01MH066237 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WOZNIAK, JANET · 2003 to 2007
$2.9M
3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M
Neural and Clinical Biomarkers of Risk for ADHD: A Focus on PreschoolersK23MH122667 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI UCHIDA, MAI · 2020 to 2024
$998k
Behavioral and Neural Response to Memantine in Adolescents with AutismK23MH100450 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JOSHI, GAGAN · 2014 to 2017
$756k
NIMH NIH HHS K23 MH100450NIMH NIH HHS K23 MH122667NIMH NIH HHS R01 MH066237NIMH NIH HHS R01 MH116037NIMH NIH HHS U01 MH109536
6 · The paper itself

Abstract

objectiveTo examine patterns of remission of pediatric bipolar I (BP-I) disorder attending to syndromatic, symptomatic, and functional outcomes from childhood to adolescent and young adult years.

methodsWe analyzed data from a six-year prospective follow-up study of youths aged 6-17 years with BP-I disorder. Subjects were comprehensively assessed at baseline and subsequently at four, five, and six years thereafter. Assessments included structured diagnostic interviews and measures of psychosocial and educational functioning. Patterns of remission were calculated attending to whether syndromatic, symptomatic, and functional remission were achieved.

resultsKaplan-Meier failure functions revealed that the probability of functional recovery from pediatric BP-I disorder was very low. Of the 88 youths assessed, only 6% (N = 5) of the sample were euthymic with normal functioning during the year prior to their last follow-up assessment (average follow-up time = 5.8 ± 1.8 years).

conclusionsThese results provide compelling evidence of the high level of persistence of pediatric BP-I disorder. Symptomatic and functional remission were uncommon and most subjects continued to demonstrate high morbidity into late adolescence and early adulthood.

Indexed as

Bipolar DisorderAdolescentAdultChildEducational StatusFollow-Up StudiesHumansProspective StudiesPsychiatric Status Rating ScalesYoung AdultAdolescentBipolar disorderPediatricPersistenceYoung adult

Identifiers

PMID35667335
PMCPMC10043808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.