Evidence map›Paper›PMID 35666490›Full record

Observational studyEuropean journal of physical and rehabilitation medicine2022

Prediction of bowel management independence after ischemic spinal cord injury.

Chiara Pavese, Giorgio Scivoletto, Mariangela V Puci, Rainer Abel, Armin Curt, Doris Maier, Rüdiger Rupp, Martin Schubert, Norbert Weidner, Cristina Montomoli and 1 more

Registry-linked trialOpen access · diamondAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of physical and rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01571531 (European Multicentre Study of Human SCI), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01571531 recruitingnot on this map

European Multicentre Study of Human SCI

TypeobservationalSponsorUniversity of ZurichRan2004 to 2026Enrolled8,000ConditionsSpinal Cord Injury
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Chiara PaveseDepartment of Neurology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Giorgio ScivolettoSpinal Cord Unit and Spinal Rehabilitation (SpiRe) Lab, IRCCS Santa Lucia Foundation, Rome, Italy.
Mariangela V PuciUnit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Rainer AbelSpinal Cord Injury Center, Hohe Warte, Bayreuth, Germany.
Armin CurtDepartment of Neurology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Doris MaierBG-Trauma Center, Murnau, Germany.
Rüdiger RuppSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Martin SchubertDepartment of Neurology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Norbert WeidnerSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Cristina MontomoliUnit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Thomas M KesslerDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland - tkessler@gmx.ch.
University of Zurich · CHUniversity of Pavia · ITBerufsgenossenschaftliche Unfallklinik Murnau · DEFondazione Santa Lucia · ITHeidelberg University · DESchön Klinik Vogtareuth · DEUniversitätsklinik Balgrist · CHUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemic spinal cord injury (SCI) belongs to the heterogeneous group of non-traumatic SCI, while the course of sensorimotor and functional recovery is comparable to traumatic SCI. Recently, we derived from data of patients with traumatic SCI a valid model to predict an independent and reliable bowel management one year after SCI.

aimTo evaluate the performance of this model to predict an independent and reliable bowel management one year following ischemic SCI.

designPrognostic study - observational study.

settingEuropean Multicenter Study about Spinal Cord Injury (EMSCI) ClinicalTrials.gov: NCT01571531. POPULATION: One hundred and forty-two patients with ischemic SCI of various level and severity of injury.

methodsThe prediction model relied on a single predictor collected within 40 days from injury, the International Standards for Neurological Classification of Spinal Cord Injury total motor score. Bowel outcome one year after SCI derived from the dichotomization of the Spinal Cord Independence Measure (SCIM) item 7 scores. We defined a positive outcome as independent bowel management with regular movements and appropriate timing with no or rare accidents (score of 10 in SCIM version II and score of 8 or 10 in version III).

resultsThe model showed a fair discrimination with an area under the receiver operating characteristic (ROC) curve of 0.780 (95% confidence interval=0.702-0.860). In addition, the model displayed an acceptable accuracy and calibration.

conclusionsThe study extends the validity of our rule to patients with ischemic SCI, thus providing the first model to predict an independent and reliable bowel management in this population. CLINICAL REHABILITATION IMPACT: The model may be employed in clinical practice to counsel patients, to define the rehabilitation aims and to estimate the need of assistance after discharge, as well as in the research field for the optimization of patients' allocation in the design of future clinical trials.

Indexed as

Spinal Cord InjuriesHumansPrognosisRecovery of FunctionROC Curve

Identifiers

PMID35666490
PMCPMC10019474
OpenAlexW4281654792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.