Evidence map›Paper›PMID 35666434›Full record

ArticleImmunologic research2022

Th17 and Th1 cells in systemic lupus erythematosus with focus on lupus nephritis.

Raouia Fakhfakh, Zeineb Zian, Nesrine Elloumi, Olfa Abida, Emna Bouallegui, Hana Houssaini, Elisabetta Volpe, Alessia Capone, Hend Hachicha, Sameh Marzouk and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raouia FakhfakhAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia. raouiafakh2@yahoo.fr.ORCID 0000-0001-5379-0622
Zeineb ZianAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Nesrine ElloumiAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Olfa AbidaAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Emna BoualleguiAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Hana HoussainiAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Elisabetta VolpeMolecular Neuroimmunology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
Alessia CaponeMolecular Neuroimmunology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
Hend HachichaAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.
Sameh MarzoukInternal Medicine Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Zouhir BahloulInternal Medicine Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Hatem MasmoudiAutoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, 3029, Sfax, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by T cells imbalance. Indeed, a correlation between levels of Th17 cells and disease activity has been reported. Our work aimed to study the functional association of subpopulations of Th cells and SLE with (lupus nephritis, LN) or without (lupus erythematosus, LE) renal involvement in Tunisian patients through the detection of intracellular cytokines and surface marker expression. The IL23R and RORC mRNA expression levels were evaluated. The level of Th17 and Th1 cells was higher in LE and LN patients compared to healthy controls (HC) (p = 0.007 and p = 0.018, respectively), while Th1/17 cells were increased only in LN patients compared to HC (p = 0.011). However, no significant difference was described in the mRNA expression levels of RORC and IL-23R between SLE and HC. Our findings suggest that the Th1/Th17 differentiation mechanisms are altered in SLE and that this imbalance should have an important influence on the development and severity of the disease.

Indexed as

Lupus Erythematosus, SystemicLupus NephritisCytokinesHumansRNA, MessengerTh17 CellsTh1 CellsTh2 CellsCytokinesRNA, MessengerCytokinesLupus nephritisSystemic lupus erythematosusTh17 cellsTh1 cells

Identifiers

PMID35666434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.