Evidence map›Paper›PMID 35666167›Full record

ArticleEuropean journal of neurology2022

Long-term independence and quality of life after subthalamic stimulation in Parkinson disease.

Anna Castrioto, Bettina Debû, Emilie Cousin, Pierre Pelissier, Eugénie Lhommée, Amélie Bichon, Emmanuelle Schmitt, Andrea Kistner, Sara Meoni, Eric Seigneuret and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Anna CastriotoInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.ORCID 0000-0002-2385-7096
Bettina DebûInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Emilie CousinCNRS LPNC UMR 5105, Grenoble Alpes University, Grenoble, France.
Pierre PelissierInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Eugénie LhomméeInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Amélie BichonInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Emmanuelle SchmittInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Andrea KistnerInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Sara MeoniInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Eric SeigneuretDepartment of Neurosurgery, Grenoble Alpes University Hospital Center, Grenoble, France.
Stephan ChabardesInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Paul KrackDepartment of Neurology, Inselspital, University Hospital Bern, Bern, Switzerland.
Elena MoroInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Valérie FraixInserm, U1216, Grenoble Alpes University Hospital Center, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Inserm · FRCentre Hospitalier Universitaire de Grenoble · FRCentre National de la Recherche Scientifique · FRUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeStudies on long-term nonmotor outcomes of subthalamic nucleus stimulation in Parkinson disease (PD) are scarce. This study reports on very long-term non-motor and motor outcomes in one of the largest cohorts of people with advanced PD, treated for >10 years with subthalamic nucleus stimulation. The main outcome was to document the evolution of independence in activities of daily living. The secondary outcomes were to measure the change in quality of life, as well as non-motor and motor outcomes.

methodsPatients were studied preoperatively, at 1 year, and beyond 10 years after subthalamic stimulation with an established protocol including motor, non-motor, and neuropsychological assessments.

resultsEighty-five people with PD were included. Independence scores in the off-medication condition (measured with the Schwab & England Activities of Daily Living Scale) as well as quality of life (measured with the Parkinson's Disease Questionnaire [PDQ]-37) remained improved at longest follow-up compared to preoperatively (respectively, p < 0.001, p = 0.015). Cognitive scores, measured with the Mattis Dementia Rating Scale, significantly worsened compared to before and 1 year after surgery (p < 0.001), without significant change in depression, measured with the Beck Depression Inventory. Motor fluctuations, dyskinesias, and off dystonia remained improved at longest follow-up (p < 0.001), with a significant reduction in dopaminergic treatment (45%, p < 0.001).

conclusionsThis study highlights the long-term improvement of subthalamic stimulation on independence and quality of life, despite the progression of disease and the occurrence of levodopa-resistant symptoms.

Indexed as

Deep Brain StimulationParkinson DiseaseActivities of Daily LivingFollow-Up StudiesHumansQuality of LifeTreatment Outcomeactivities of daily livingdeep brain stimulationParkinson diseasequality of lifesubthalamic nucleus

Identifiers

PMID35666167
PMCPMC9543065
OpenAlexW4281619665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.