Evidence map›Paper›PMID 35666091›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Bioactive, full-length parathyroid hormone delivered using an adeno-associated viral vector.

Alexandra M Burr, Pamela Cabahug Zuckerman, Alesha B Castillo, Nicola C Partridge, Biju Parekkadan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexandra M BurrDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0002-7954-3619
Pamela Cabahug ZuckermanDepartment of Orthopedic Surgery, NYU Langone Health, New York University, New York, NY 10016, USA.
Alesha B CastilloDepartment of Orthopedic Surgery, NYU Langone Health, New York University, New York, NY 10016, USA.
Nicola C PartridgeDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA.
Biju ParekkadanDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · USVA NY Harbor Healthcare System · USNew York University · US

Funding

Artificial, Humanized Stem Cell NichesR01EB012521 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI PAREKKADAN, BIJU · 2011 to 2021
$6.0M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservationR01EB028782 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Biju Parekkadan, Korkut Uygun · 2021 to 2026
$3.1M
Osteo-Angio Coupling During Bone Repair - Resubmission - 1R01AR073864 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEUCHT, PHILIPP · 2019 to 2023
$2.2M
NRSA TrainingTL1TR003019 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI SCOTTO, KATHLEEN W. · 2019 to 2023
$1.9M
NCATS NIH HHS TL1 TR003019NIAMS NIH HHS R01 AR073864NIBIB NIH HHS R01 EB012521NIBIB NIH HHS R01 EB028782NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

Delivering the parathyroid hormone (PTH) gene has been attempted preclinically in a handful of studies, but delivering full-length PTH (1-84) using adeno-associated viral (AAV) vectors has not. Given the difficulty in achieving therapeutic levels of secreted proteins using gene therapy, this study seeks to determine the feasibility of doing so with PTH. An AAV vector was used to deliver human PTH driven by a strong promoter. We demonstrate the ability to secrete full-length PTH from various cell types

Indexed as

Parathyroid HormoneAnimalsHumansMiceParathyroid HormoneAAV-PTHAAV vectorHypoparathyroidismparathyroid hormone

Identifiers

PMID35666091
PMCPMC9742744
OpenAlexW4281693437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.