Evidence map›Paper›PMID 35666066›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients.

Joanna Sophia J Vinke, Hanneke J C M Wouters, Suzanne P Stam, Rianne M Douwes, Adrian Post, Antonio W Gomes-Neto, Melanie M van der Klauw, Stefan P Berger, Stephan J L Bakker, TransplantLines Investigators and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Joanna Sophia J VinkeDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Hanneke J C M WoutersDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Suzanne P StamDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Rianne M DouwesDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Adrian PostDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Antonio W Gomes-NetoDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Melanie M van der KlauwDepartment of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stefan P BergerDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stephan J L BakkerDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
TransplantLines InvestigatorsGroningen Transplant Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Martin H De BorstDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Michele F EisengaDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-2484-6233
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-transplant anaemia and reduced muscle mass and strength are highly prevalent in kidney transplant recipients (KTRs). Decreased haemoglobin levels, a marker of anaemia, could adversely affect muscle mass and strength through multiple mechanisms, among others, through diminished tissue oxygenation. We aimed to investigate the association between haemoglobin levels with muscle mass and strength in KTRs.

methodsWe included stable KTRs from the TransplantLines Biobank and Cohort study with a functional graft ≥1 year post-transplantation. Muscle mass was assessed using 24 h urinary creatinine excretion rate (CER) and bioelectrical impedance analysis (BIA). Muscle strength was assessed with a handgrip strength test using a dynamometer and, in a subgroup (n = 290), with the five-times sit-to-stand (FTSTS) test. We used multivariable linear and logistic regression analyses to investigate the associations of haemoglobin levels with muscle mass and strength.

resultsIn 871 included KTRs [median age 58 (interquartile range (IQR), 48-66)] years; 60% men; eGFR 51 ± 18 mL/min/1.73 m

conclusionsLow haemoglobin levels are strongly associated with decreased muscle mass and strength in KTRs. Future investigation will need to investigate whether maintaining higher haemoglobin levels may improve muscle mass and strength in KTRs.

Indexed as

AnemiaHand StrengthHemoglobinsKidney TransplantationMuscle, SkeletalAgedCohort StudiesFemaleHumansMaleMiddle AgedHemoglobins24 h urinary creatinine excretionHaemoglobin levelsHandgrip strengthKidney transplant recipients

Identifiers

PMID35666066
PMCPMC9397498
OpenAlexW4281680087

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.