ArticleAnimal models and experimental medicine2022
Continuous cardiac output measured with a Swan-Ganz catheter reacts too slowly in animal experiments with sudden circulatory failure.
Article in Animal models and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 5 citations in OpenAlex.
- Moving-average processing enables accurate quantification of time delay and compares the trending ability of cardiac output monitors with different response times.BMC biomedical engineering · 2025Article
- Capnodynamic assessment of mixed venous oxygen saturation in a porcine experimental endotoxemic model.Scientific reports · 2024Article
- Hypoxia in the pulmonary vein increases pulmonary vascular resistance independently of oxygen in the pulmonary artery.Animal models and experimental medicine · 2024Article
- Capnodynamics - noninvasive cardiac output and mixed venous oxygen saturation monitoring in children.Frontiers in pediatrics · 2023Review
- Continuous cardiac output measured with a Swan-Ganz catheter reacts too slowly in animal experiments with sudden circulatory failure.Animal models and experimental medicine · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn many animal experiments, it is vital to detect sudden changes in cardiac output (CO). This porcine study compared CO that was measured with a Swan-Ganz pulmonary catheter with the gold standard (which was a transit-time flow probe around the pulmonary artery) during interventions that caused hemodynamic instability.
methodsIn one series, 7 pigs were exposed to sudden changes in CO. In another series, 9 pigs experienced more prolonged changes in CO. All the pigs had a Swan-Ganz catheter placed into the pulmonary artery and a flow probe around the pulmonary artery. Adrenaline infusion and controlled hemorrhage were used to increase and decrease CO, respectively. The measurements of CO before and after each intervention were compared for correlation, agreement, and the time delay that it took each method to detect at least a 30% change in CO. A Bland-Altman test was used to identify correlations and agreements between the methods.
resultsIn the first series, there was a delay of 5-7 min for the Swan Ganz catheter to register a 30% change in cardiac output, compared with the flow probe. However, during prolonged changes in CO in the second series, there was a good correlation between the 2 methods. Mixed venous oxygen saturation reacted faster to changes than did CO; both were measured via the Swan-Ganz catheter.
conclusionsIn many animal studies, the use of Swan-Ganz catheters is suitable; however, in experiments with sudden hemodynamic instability, the flow probe is the most advantageous method for measuring CO.
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