Evidence map›Paper›PMID 35665921›Full record

Observational studyDevelopmental medicine and child neurology2023

Temporal trends, clinical characteristics, and sociodemographic profile of post-neonatally acquired cerebral palsy in Australia, 1973-2012: A population-based observational study.

Emma Waight, Sarah McIntyre, Susan Woolfenden, Linda Watson, Susan Reid, Heather Scott, Tanya Martin, Annabel Webb, Nadia Badawi, Hayley Smithers-Sheedy and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Developmental medicine and child neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Emma WaightCerebral Palsy Alliance/Research Institute, Specialty of Child & Adolescent Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-8027-6183
Sarah McIntyreCerebral Palsy Alliance/Research Institute, Specialty of Child & Adolescent Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-0234-1541
Susan WoolfendenFaculty of Medicine, School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-6954-5071
Linda WatsonWestern Australian Register of Developmental Anomalies, Perth, WA, Australia.
Susan ReidMurdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0001-9415-5246
Heather ScottWomen's and Children's Health Network, Adelaide, SA, Australia.
Tanya MartinSchool of Nursing and Midwifery, The University of Sydney, Camperdown, NSW, Australia.
Annabel WebbCerebral Palsy Alliance/Research Institute, Specialty of Child & Adolescent Health, The University of Sydney, Camperdown, NSW, Australia.
Nadia BadawiCerebral Palsy Alliance/Research Institute, Specialty of Child & Adolescent Health, The University of Sydney, Camperdown, NSW, Australia.
Hayley Smithers-SheedyCerebral Palsy Alliance/Research Institute, Specialty of Child & Adolescent Health, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-0082-2413
Australian Cerebral Palsy Register Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo describe post-neonatally acquired (PNN) cerebral palsy (CP) in terms of temporal trends in prevalence, clinical and sociodemographic profiles, known causes and associations between causes, and sociodemographic variables.

methodNumerator data, a count of children with PNN-CP confirmed at 5 years of age (n = 523), was drawn from two Australian state CP registers (birth years 1973-2012). Poisson regression was used to investigate temporal trends in the prevalence of PNN-CP by 5-year intervals, calculated per 10 000 live births. Using data from all state and territory Australian CP registers (n = 469), distributions of clinical characteristics, PNN-CP causes, and sociodemographic factors were tabulated (birth years 1995-2012). χ

resultsA significant temporal decline in PNN-CP in Victoria (p = 0.047) and Western Australia (p = 0.033) was observed. The most common proximal causes of PNN-CP were cerebrovascular accidents (34%, n = 158), infection (25%, n = 117), and non-accidental injuries (12%, n = 58). Children born to teenage mothers, Aboriginal and/or Torres Strait Islander mothers, or children born in remote areas were over-represented in this cohort compared with reference data (all p ≤ 0.001). Infectious causes were strongly associated with teenage motherhood (odds ratio 3.0 [95% confidence interval 1.1-8.2], p = 0.028) and remote living (odds ratio 4.5 [95% confidence interval 2.0-10.2], p < 0.001).

interpretationAlthough prevalence of PNN-CP has declined, the over-representation of priority populations, and the relative severity of a condition that is largely preventable, suggest the need for more specific primary preventive measures and support. WHAT THIS PAPER ADDS: Prevalence of post-neonatally acquired (PNN) cerebral palsy (CP) in Australia significantly declined between 1973 and 2012. Cerebrovascular accidents are the most common proximal cause of PNN-CP. Children born in remote areas are at greater risk of PNN-CP.

Indexed as

Cerebral PalsyStrokeAdolescentChildCohort StudiesFemaleHumansPrevalenceVictoria

Identifiers

PMID35665921
PMCPMC10952665

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.