ArticleDiabetologia2022
Obesity in late adolescence and incident type 1 diabetes in young adulthood.
Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Adolescent obesity and risk of serious chronic morbidity and mortality in young adulthood: a systematic review of cohorts from national registries.Cardiovascular diabetology · 2026Pooled it
- High BMI and the risk for incident type 1 Diabetes Mellitus: a systematic review and meta-analysis of aggregated cohort studies.Cardiovascular diabetology · 2023Pooled it
- Effects of an Exercise Program on Cardiometabolic and Mental Health in Children With Overweight or Obesity: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2023Trial
- Lifestyle and environmental risk factors for adult-onset autoimmune diabetes: current evidence and future directions.Diabetologia · 2026Review
- Pancreatic islets: new discoveries for innovative treatments of diabetes?Diabetologia · 2026Review
- Obesity in Late Adolescence and Healthcare Costs in Young to Mid-Adulthood.Diabetes, obesity & metabolism · 2026Article
- Review
- Thyroid, Celiac, and Other Autoimmune Diseases and the Risk of Incident Type 1 Diabetes in Young Adulthood.Diabetes care · 2026Article
- Trends in adolescent obesity in the Arab ethnic minority in Israel: an age-period-cohort analysis.BMC public health · 2025Article
- Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data.Journal of translational autoimmunity · 2025Article
- Ethnic Differences in Weight Category Transition and Body Mass Index Trajectories from Adolescence to Young Adulthood in Israel.Children (Basel, Switzerland) · 2025Article
- Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection.Annals of pediatric endocrinology & metabolism · 2025Article
- Immune cell-adipose tissue crosstalk in metabolic diseases with a focus on type 1 diabetes.Diabetologia · 2025Review
- Adolescent Body Mass Index, Weight Trajectories to Adulthood, and Osteoporosis Risk.JAMA network open · 2025Article
- Gestational diabetes and parental type 2 diabetes as risk indicators for type 1 diabetes in offspring: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Plasticity deficits of Tregs remodeling toward Th1-like and Th17-like Tregs in individuals with type 1 diabetes.Journal of endocrinological investigation · 2025Article
- Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance.Endocrine reviews · 2025Review
- The obesity pandemic and its impact on non-communicable disease burden.Pflugers Archiv : European journal of physiology · 2025Review
- Managing obesity in adults with type 1 diabetes.Diabetes research and clinical practice · 2025Review
- Adolescent Obesity and Charlson Comorbidity Index in Young Adults.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisStudies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood.
methodsAll Israeli adolescents, ages 16-19 years, undergoing medical evaluation in preparation for mandatory military conscription between January 1996 and December 2016 were included for analysis unless they had a history of dysglycaemia. Data were linked with information about adult onset of type 1 diabetes in the Israeli National Diabetes Registry. Weight and height were measured at study entry. Cox proportional models were applied, with BMI being analysed both as a categorical and as a continuous variable.
resultsThere were 777 incident cases of type 1 diabetes during 15,819,750 person-years (mean age at diagnosis 25.2±3.9 years). BMI was associated with incident type 1 diabetes. In a multivariable model adjusted for age, sex and sociodemographic variables, the HRs for type 1 diabetes were 1.05 (95% CI 0.87, 1.27) for the 50th-74th BMI percentiles, 1.41 (95% CI 1.11, 1.78) for the 75th-84th BMI percentiles, 1.54 (95% CI 1.23, 1.94) for adolescents who were overweight (85th-94th percentiles), and 2.05 (95% CI 1.58, 2.66) for adolescents with obesity (≥95th percentile) (reference group: 5th-49th BMI percentiles). One increment in BMI SD was associated with a 25% greater risk for incidence of type 1 diabetes (HR 1.25, 95% CI 1.17, 1.32).
conclusionsExcessively high BMI in otherwise healthy adolescents is associated with increased risk for incident type 1 diabetes in early adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.