Evidence map›Paper›PMID 35665752›Full record

ArticleScientific reports2022

Association of protein function-altering variants with cardiometabolic traits: the strong heart study.

Yue Shan, Shelley A Cole, Karin Haack, Phillip E Melton, Lyle G Best, Christopher Bizon, Sayuko Kobes, Çiğdem Köroğlu, Leslie J Baier, Robert L Hanson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Yue ShanDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Shelley A ColeTexas Biomedical Research Institute, San Antonio, TX, USA.
Karin HaackTexas Biomedical Research Institute, San Antonio, TX, USA.
Phillip E MeltonThe Curtin UWA Centre for Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University and Faculty of Health and Medical Sciences, The University of Western Australia, Crawley, WA, Australia.
Lyle G BestMissouri Breaks Industries Research Inc, Eagle Butte, SD, USA.
Christopher BizonRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
Sayuko KobesPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Bethesda, USA.
Çiğdem KöroğluPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Bethesda, USA.
Leslie J BaierPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Bethesda, USA.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Bethesda, USA.
Serena SannaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Yun LiDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. noraf@unc.edu.
University of North Carolina at Chapel Hill · USTexas Biomedical Research Institute · USMissouri Breaks Industries Research (United States) · USRenaissance Computing Institute · USUniversity Medical Center Groningen · NLUniversity of Tasmania · AU

Funding

The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
STRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
STRONG HEART STUDY (SHS)-MISSOURI BREAKS INDUSTRIES RESEARCH, INC.- FIELD CENTER (FC) TASK AREA B (B.1 AND B.3)75N92019D00029 · NHLBI · MISSOURI BREAKS RESEARCH, INC. · PI FRETTS, AMANDA MAE · 2019 to 2025
$7.5M
STRONG HEART STUDY (SHS)- UNIVERSITY OF OKLAHOMA-FIELD CENTER (FC), TASK AREA B.3, YEAR 375N92019D00028 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ALI, TAUQEER · 2019 to 2025
$6.5M
STRONG HEART STUDY (SHS)- MEDSTAR HEALTH RESEARCH INSTITUTE (MHRI) FIELD CENTER -SUBTASK AREA B.2 PHASE VII EXAM AND EXAM CLOSEOUT.75N92019D00030 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2019 to 2025
$5.2M
CVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
CVD in American Indians Biomarker lab and Arizona Field CenterR01HL109319 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2013 to 2017
$3.6M
NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS R21 HL140385NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIDDK NIH HHS R01 DK117445NIH HHS HL140385NIMHD NIH HHS R01 MD012765
6 · The paper itself

Abstract

Clinical and biomarker phenotypic associations for carriers of protein function-altering variants may help to elucidate gene function and health effects in populations. We genotyped 1127 Strong Heart Family Study participants for protein function-altering single nucleotide variants (SNV) and indels selected from a low coverage whole exome sequencing of American Indians. We tested the association of each SNV/indel with 35 cardiometabolic traits. Among 1206 variants (average minor allele count = 20, range of 1 to 1064), ~ 43% were not present in publicly available repositories. We identified seven SNV-trait significant associations including a missense SNV at ABCA10 (rs779392624, p = 8 × 10

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2FastingGenetic Predisposition to DiseaseGlucoseHumansInsulinPolymorphism, Single NucleotideReceptors, GABAGlucoseInsulinReceptors, GABATSPO protein, human

Identifiers

PMID35665752
PMCPMC9167281
OpenAlexW4281708382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.