Evidence map›Paper›PMID 35665647›Full record

ArticleNeurobiology of aging2022

Advanced age has dissociable effects on hippocampal CA1 ripples and CA3 high frequency events in male rats.

Nicholas M DiCola, Alexa L Lacy, Omar J Bishr, Kathryn M Kimsey, Jenna L Whitney, Sarah D Lovett, Sara N Burke, Andrew P Maurer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicholas M DiColaEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Alexa L LacyEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Omar J BishrEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Kathryn M KimseyEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Jenna L WhitneyEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Sarah D LovettEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Sara N BurkeEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA. Electronic address: burkes@ufl.edu.
Andrew P MaurerEvelyn F. McKnight McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA; Engineering School of Sustainable Infrastructure and Environment, University of Florida, Gainesville, FL, USA. Electronic address: drewmaurer@ufl.edu.
University of Florida · US

Funding

The contribution of declines in functional connectivity to cognitive agingR01AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2016 to 2025
$3.2M
The contribution of declines in functional connectivity to cognitive agingRF1AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2021 to 2021
$2.0M
Age-associated changes in hippocampal circuits and cognitive functionR01AG055544 · NIA · UNIVERSITY OF FLORIDA · PI MAURER, ANDREW PORTER · 2017 to 2021
$1.9M
Metabolic Interventions for Enhancing Cognitive Resilience in Aging and Alzheimers DiseaseRF1AG060977 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2019 to 2019
$1.9M
Clinical and Translational Predoctoral training in Alzheimers Disease and Related DementiasT32AG061892 · NIA · UNIVERSITY OF FLORIDA · PI PARAMITA CHAKRABARTY, JADA M LEWIS · 2018 to 2026
$1.8M
NIA NIH HHS R01 AG049722NIA NIH HHS R01 AG055544NIA NIH HHS RF1 AG049722NIA NIH HHS RF1 AG060977NIA NIH HHS T32 AG061892
6 · The paper itself

Abstract

Sharp wave/ripples/high frequency events (HFEs) are transient bursts of depolarization in hippocampal subregions CA3 and CA1 that occur during rest and pauses in behavior. Previous studies have reported that CA1 ripples in aged rats have lower frequency than those detected in young animals. While CA1 ripples are thought to be driven by CA3, HFEs in CA3 have not been examined in aged animals. The current study obtained simultaneous recordings from CA1 and CA3 in young and aged rats to examine sharp wave/ripples/HFEs in relation to age. While CA1 ripple frequency was reduced with age, there were no age differences in the frequency of CA3 HFEs, although power and length were lower in old animals. While there was a proportion of CA1 ripples that co-occurred with a CA3 HFE, none of the age-related differences in CA1 ripples could be explained by alterations in CA3 HFE characteristics. These findings suggest that age differences in CA1 are not due to altered CA3 activity, but instead reflect distinct mechanisms of ripple generation with age.

Indexed as

CA1 Region, HippocampalHippocampusAction PotentialsAnimalsMaleRatsCo-OccurrenceEntorhinal cortexLocal field potentialRatSharp waveSynapse

Identifiers

PMID35665647
PMCPMC9392897
OpenAlexW4229006603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.