Evidence map›Paper›PMID 35665537›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Acyl-CoA:wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina.

Made Airanthi K Widjaja-Adhi, Alexander V Kolesnikov, Sreelakshmi Vasudevan, Paul S-H Park, Vladimir J Kefalov, Marcin Golczak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Made Airanthi K Widjaja-AdhiDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.
Alexander V KolesnikovDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California, USA.
Sreelakshmi VasudevanDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Paul S-H ParkDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Vladimir J KefalovDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California, USA.
Marcin GolczakDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Regulation of vitamin A metabolism in the eyeR01EY023948 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI GOLCZAK, MARCIN BERNARD · 2014 to 2023
$3.8M
Opsin signaling in mammalian rod photoreceptorsR01EY030912 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV, PALCZEWSKI, KRZYSZTOF · 2020 to 2023
$1.6M
PIGMENT DEPHOSPHORYLATION IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY025696 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2016 to 2019
$1.5M
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY023948NEI NIH HHS R01 EY025696NEI NIH HHS R01 EY030912
6 · The paper itself

Abstract

The daylight and color vision of diurnal vertebrates depends on cone photoreceptors. The capability of cones to operate and respond to changes in light brightness even under high illumination is attributed to their fast rate of recovery to the ground photosensitive state. This process requires the rapid replenishing of photoisomerized visual chromophore (11-cis-retinal) to regenerate cone visual pigments. Recently, several gene candidates have been proposed to contribute to the cone-specific retinoid metabolism, including acyl-CoA wax alcohol acyltransferase 2 (AWAT2, aka MFAT). Here, we evaluated the role of AWAT2 in the regeneration of visual chromophore by the phenotypic characterization of Awat2

Indexed as

Retinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsAcyl Coenzyme AAcyltransferasesAnimalsMiceRetinaRetinaldehydeAcyl Coenzyme AAcyltransferasesAWAT2 protein, mouseethanol acyltransferaseRetinaldehydeAWAT2cone visual cycledark adaptationMFATvisual chromophore

Identifiers

PMID35665537
PMCPMC9205179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.