SynthesisClinical cardiology2022
Mechanical or biologic prostheses for mitral valve replacement: A systematic review and meta-analysis.
Synthesis in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Bioprosthetic versus mechanical valves for mitral valve replacement in patients < 70 years: an updated pairwise meta-analysis.General thoracic and cardiovascular surgery · 2024Pooled it
- Mechanical or biologic prostheses for mitral valve replacement: A systematic review and meta-analysis.Clinical cardiology · 2022Pooled it
- Evolutions in Cardiovascular Implants-A Review of Past, Present, and Future.Micromachines · 2026Review
- The choice of mitral valve surgery type and mid-term outcomes in patients up to 70 years of age: Results of the AUTHEARTVISIT study.JTCVS open · 2026Article
- Alterations in endothelial activation biomarkers ICAM-1 and VCAM-1 following mitral regurgitation surgery.Turkish journal of surgery · 2026Article
- Bovine Pericardial Versus Porcine Mitral Valve Replacement: A Propensity-Matched Analysis of Mid-Term Durability Outcomes.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Survival and Cost Analysis of Surgical Mitral Valve Replacement With Different Prostheses: A Nationwide Cohort Study in Taiwan.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- A protocol of 'A post-market national POLish registry of biological prostheses with RESilia tissue (POLRES)'.Cardiology journal · 2025Article
- Outcomes of aortic and mitral valve replacement with Dafodil™ pericardial bioprosthesis over 5-years: Dafodil™-1 trial.Frontiers in cardiovascular medicine · 2025Article
- Concurrent transapical transcatheter aortic valve and mitral valve-in-ring replacement for aortic regurgitation.ESC heart failure · 2024Article
- Long-term outcomes following mitral valve replacement in children at heart center Leipzig: a 20-year analysis.Journal of cardiothoracic surgery · 2024Article
- Long-term outcomes of isolated mechanical versus bioprosthetic mitral valve replacement in different age groups of propensity-matched patients.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Observational
- Performance characterization and biocompatibility assessment of silicone polyurethanes for polymer heart valve applications.RSC advances · 2024Article
- A comparison of neurological event and mortality rates between transcatheter aortic valve implantation and surgical aortic valve replacement.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Review
- Mid-term outcomes of the COMMENCE trial investigating mitral valve replacement using a bioprosthesis with a novel tissue.JTCVS open · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Either a mechanical or bioprosthetic valve is used in patients undergoing mitral valve replacement (MVR). However, the optimal mitral prosthesis remains controversial. The aim of this meta-analysis was thus to compare outcomes between mechanical mitral valve replacement (MVRm) and bioprosthetic mitral valve replacement (MVRb) for MVR patients. We searched Embase, PubMed, Web of Science, and Cochrane Library databases from January 1, 2000 to October 31, 2021 for studies that directly compared surgical outcomes of MVRm and MVRb. A total of 22 studies with 35 903 patients were included in the meta-analysis (n = 23 868 MVRm and n = 12 035 MVRb). The MVRm group displayed lower long-term all causes mortality (HR, 0.84; 95% confidence interval [CI]: 0.77-0.91; p < .0001; I² = 51%), and fewer mitral reoperation (hazard ratio [HR]: 0.34; 95% CI: 0.23-0.50; p < .00001; I² = 74%) than MVRb group. However, the MVRm group was associated with a greater risk of major bleeding events (HR: 1.21; 95% CI: 1.14-1.29; p < .00001; I² = 0%), stroke and systemic embolism (HR: 1.20; 95% CI: 1.10-1.32; p < .0001; I² = 0%) in matched or adjusted data. No significant difference was observed between MVRm and MVRb on operative mortality in matched/adjusted group (risk ratios: 0.83; 95% CI: 0.66-1.05; p = .12; I² = 0%). The results were consistent with patients aged under 70 years old. Patients who received a MVRm is associated with 16% lower risk of long-term mortality and 66% lower risk of mitral reoperation, but 20% greater risk of stroke or systemic embolism, 21% greater risk of major bleeding compared with MVRb in matched/adjusted studies group, which were consistent to patients younger than the age of 70 years who underwent MVR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.