ArticleActa physiologica (Oxford, England)2022
Regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish.
Article in Acta physiologica (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- A genetic model for development, physiology and behavior of catecholamine-deficient zebrafish larvae.Communications biology · 2026Article
- Melanophore physiology and adrenergic receptor signaling in zebrafish (Danio rerio).Fish physiology and biochemistry · 2026Review
- Review
- Regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish.Acta physiologica (Oxford, England) · 2022Article
- Acquirement of the autonomic nervous system modulation evaluated by heart rate variability in medaka (Oryzias latipes).PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough zebrafish are gaining popularity as biomedical models of cardiovascular disease, our understanding of their cardiac control mechanisms is fragmentary. Our goal was to clarify the controversial role of the ß1-adrenergic receptor (AR) in the regulation of heart rate in zebrafish.
methodsCRISPR-Cas9 was used to delete the adrb1 gene in zebrafish allowing us to generate a stable adrb1
resultsCompared with genetically matched wild-types (adrb1
conclusionDespite adrb1 contributing to the setting of resting heart rate in larvae, it is not strictly essential for zebrafish, as we generated a viable and breeding adrb1
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