ArticleFrontiers in physiology2022
Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson's Disease.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- Synchronization of delayed coupled neurons with multiple synaptic connections.Cognitive neurodynamics · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- Suppression of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model.Journal of biological physics · 2023Article
- Delay-dependent transitions of phase synchronization and coupling symmetry between neurons shaped by spike-timing-dependent plasticity.Cognitive neurodynamics · 2023Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson's Disease patients.Frontiers in human neuroscience · 2023Article
- Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson's disease.Frontiers in neurology · 2023Review
- Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review.Frontiers in aging neuroscience · 2023Article
- Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?Frontiers in pharmacology · 2022Review
- Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation.Frontiers in human neuroscience · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia (BG) circuitry. Dopamine (DA) depletion in experimental PD models leads to the pathological strengthening of pallido-subthalamic synaptic connections, contributing to the emergence of abnormally synchronized neuronal activity in the external segment of the globus pallidus (GPe) and subthalamic nucleus (STN). Augmented GPe-STN transmission following loss of DA was attributed to heterosynaptic plasticity mechanisms induced by cortico-subthalamic inputs. However, synaptic plasticity may play a role in this process. Here, by employing computational modeling we show that assuming inhibitory spike-timing-dependent plasticity (iSTDP) at pallido-subthalamic synapses can account for pathological strengthening of pallido-subthalamic synapses in PD by further promoting correlated neuronal activity in the GPe-STN network. In addition, we show that GPe-STN transmission delays can shape bistable activity-connectivity states due to iSTDP, characterized by strong connectivity and strong synchronized activity (pathological states) as opposed to weak connectivity and desynchronized activity (physiological states). Our results may shed light on how abnormal reshaping of GPe-STN connectivity by synaptic plasticity during parkinsonism is related to the PD pathophysiology and contribute to the development of therapeutic brain stimulation techniques targeting plasticity-induced rewiring of network connectivity.
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