ArticleFrontiers in neurology2022
The "Black Straight-Line Sign" in the Putamen in Diffusion-Weighted Imaging: A Potential Diagnostic MRI Marker for Multiple System Atrophy.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Distinct EEG functional network alterations in Parkinson's disease and multiple system atrophy.NeuroImage. Clinical · 2026Article
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9 authors at 2 institutions in 1 country.
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Abstract
Background and Purpose: The diagnosis of multiple system atrophy (MSA) remains challenging in clinical practice. This study investigated the value of hypointense signals in the putamen ("black straight-line sign") in diffusion-weighted imaging (DWI) of brain MRI for distinguishing (MSA) from Parkinson's disease (PD). Methods: We retrospectively enrolled 30 MSA patients, 30 PD patients, and 30 healthy controls who had undergone brain MRI between 2016 and 2020. Two readers independently assessed the signal intensity of the bilateral putamen on DWI. The putaminal hypointensity was scored using 4-point visual scales. Putaminal hypointensity and the presence of a "black straight-line sign" were statistically compared between MSA and PD or healthy controls. Results: The mean scores of putaminal hypointensity in DWI in the MSA group were significantly higher than in both the PD ( Conclusion: The "black straight-line sign" of the putamen in DWI of head MRIs has the potential to serve as a diagnostic marker for distinguishing MSA from PD.
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