ArticleFrontiers in neurology2022
Medial Temporal Atrophy Contributes to Cognitive Impairment in Cerebral Small Vessel Disease.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.Neuroimage. Reports · 2026Review
- Mapping the Association of Cerebral Small Vessel Disease, Gray Matter Integrity, and Cognitive Function.Neurology · 2025Article
- Voxel-based morphometry reveals gray matter atrophy in cerebral small vessel disease: correlation with cognitive impairment.Quantitative imaging in medicine and surgery · 2025Article
- Neuroimaging and Genetic Markers of Cerebral Small Vessel Disease and Cognitive Outcomes: A Systematic Review and Meta-Analysis (NEUROGEN-SVD Study).Diagnostics (Basel, Switzerland) · 2025Article
- Cortical structural degeneration and functional network connectivity changes in patients with subcortical vascular cognitive impairment.Neuroradiology · 2025Article
- A point-based cognitive impairment scoring system for southeast Asian adults.The journal of prevention of Alzheimer's disease · 2025Article
- Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.Neuroradiology · 2025Article
- Deep medullary veins disruption in cerebral small vessel disease: links to AI-quantified lesions and cognitive decline.Frontiers in neurology · 2025Article
- Hemodynamic changes and their relationship with white matter hyperintensities in CSVD patients with cognitive impairment: a 4D flow study.Frontiers in aging neuroscience · 2025Article
- Subcortical volumes and cognition in CADASIL - A pilot study.Cerebral circulation - cognition and behavior · 2024Article
- Dynamic functional network connectivity in patients with a mismatch between white matter hyperintensity and cognitive function.Frontiers in aging neuroscience · 2024Article
- Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease.Frontiers in neuroscience · 2024Article
- Fractal dimension of the cortical gray matter outweighs other brain MRI features as a predictor of transition to dementia in patients with mild cognitive impairment and leukoaraiosis.Frontiers in human neuroscience · 2023Article
- Association between morphologic features of intracranial distal arteries and brain atrophy indexes in cerebral small vessel disease: a voxel-based morphometry study.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of brain atrophy in cognitive decline related to cerebral small vessel disease (CSVD) remains unclear. This study used AccuBrain™ to identify major CSVD-related brain changes and verified the relationship between brain atrophy and different cognition domains in CSVD patients. Methods: All enrolled 242 CSVD patients and 76 healthy participants underwent magnetic resonance imaging examinations and detailed neuropsychological scale assessments were collected at the same time. The AccuBrain™ technology was applied to fully automated image segmentation, measurement, and calculation of the acquired imaging results to obtain the volumes of different brain partitions and the volume of WMH for quantitative analysis. Correlation analyses were used to estimate the relationship between MRI features and different cognitive domains. Multifactor linear regression models were performed to analyze independent predictors of MTA and cognitive decline. Results: CSVD patients exhibited multiple gray matter nucleus volume decreases in the basal ganglia regions and brain lobes, including the temporal lobe ( Conclusions: Our results showed that MTA was related to cognition impairment in CSVD patients, which might become a potential imaging marker for CSVD-CI.
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