ArticleResearch square2022
The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection.
Tapas Hazra, Nisha Tapryal, Anirban Chakraborty, Kempaiah Rayavara, Maki Wakamiya, Azharul Islam, Lang Pan, Jason Hsu, Vivian Tat, Junki Maruyama and 17 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
27 authors at 7 institutions in 2 countries.
Nisha TapryalThe University of Texas Medical Branch at Galveston.
Anirban ChakrabortyThe University of Texas Medical Branch at Galveston.
Maki WakamiyaThe University of Texas Medical Branch at Galveston.
Azharul IslamThe University of Texas Medical Branch at Galveston.
Lang PanThe University of Texas Medical Branch at Galveston.
Vivian TatUniversity of Texas Medical Branch.
Koa HosokiBaylor College of Medicine.
Ibrahim SayedUniversity of California, San Diego.
Vanessa CastilloUniversity of California San Diego.
Courtney TindleUniversity of California, San Diego.
Victor CardenasThe University of Texas Medical Branch at Galveston.
Gulshan SharmaThe University of Texas Medical Branch at Galveston.
Laura Crotty AlexanderUniversity of California.
Sanjiv SurBaylor College of Medicine.
Gourisankar GhoshUniversity of California, San Diego.
Slobodan PaesslerUniversity of Texas Medical Branch at Galveston.
Istvan BoldoghUniversity of Texas Medical Branch at Galveston.
The University of Texas Medical Branch at Galveston · USUniversity of California San Diego · USBaylor College of Medicine · USLawrence Berkeley National Laboratory · USUC San Diego Health System · USUniversidad Católica Santo Domingo · DOUniversity of California System · US
Funding
Virus, Tissue Culture and ImmunoassayP01AI062885 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CASOLA, ANTONELLA · 2005 to 2022
$23.9MMacrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9MSARS-CoV-2 tropism in the brain and its relationship to COVID-19 pathogenesisR01HL163814 · NHLBI · UNIVERSITY OF NORTH DAKOTA · PI LAZARTIGUES, ERIC D, YAKOUB, ABRAAM M. · 2021 to 2021
$4.3MRole of Cytosolic DNA-multiprotein Interactome in Allergic Airway InflammationR01HL145477 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K, SUR, SANJIV · 2019 to 2022
$3.6MPreferential single-strand break repair in the active genes of mammalian cellsR01NS073976 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K · 2012 to 2021
$3.3MModulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2MInnate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2MSummer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0MPrecision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937kViral factors responsible for Lassa virus pathogenicityK99AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2021 to 2022
$177kNCATS NIH HHS UG3 TR003355NHLBI NIH HHS R01 HL145477NHLBI NIH HHS R01 HL163814NIAID NIH HHS HHSN272201700040INIAID NIH HHS K99 AI156012NIAID NIH HHS P01 AI062885NIAID NIH HHS R01 AI141630NIAID NIH HHS R01 AI155696NIDDK NIH HHS R01 DK107585NIGMS NIH HHS R01 GM138385NINDS NIH HHS R01 NS073976
6 · The paper itselfAbstract
Compromised DNA repair capacity of individuals could play a critical role in the severity of SARS-CoV-2 infection-induced COVID-19. We therefore analyzed the expression of DNA repair genes in publicly available transcriptomic datasets of COVID-19 patients and found that the level of NEIL2, an oxidized base specific mammalian DNA glycosylase, is particularly low in the lungs of COVID-19 patients displaying severe symptoms. Downregulation of pulmonary NEIL2 in CoV-2-permissive animals and postmortem COVID-19 patients validated these results. To investigate the potential roles of NEIL2 in CoV-2 pathogenesis, we infected
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