Evidence map›Paper›PMID 35664999›Full record

ArticlemedRxiv : the preprint server for health sciences2022

A repeat pattern of founder events for SARS-CoV-2 variants in Alaska.

Tracie J Haan, Lisa K Smith, Stephanie DeRonde, Elva House, Jacob Zidek, Diana Puhak, Logan Mullen, Matthew Redlinger, Jayme Parker, Brian M Barnes and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Tracie J HaanInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
Lisa K SmithAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Stephanie DeRondeAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Elva HouseAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Jacob ZidekAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Diana PuhakAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Logan MullenInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
Matthew RedlingerDepartment of Biological Sciences, University of Alaska Anchorage, Anchorage, Alaska, USA.
Jayme ParkerAlaska Division of Public Health, State of Alaska, Fairbanks, Alaska, USA.
Brian M BarnesInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
Jason L BurkheadDepartment of Biological Sciences, University of Alaska Anchorage, Anchorage, Alaska, USA.
Cindy KnallWWAMI School of Medical Education, University of Alaska Anchorage, Anchorage, Alaska, USA.
Eric BortzDepartment of Biological Sciences, University of Alaska Anchorage, Anchorage, Alaska, USA.
Jack ChenInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
Devin M DrownInstitute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
NIGMS NIH HHS P20 GM103395
6 · The paper itself

Abstract

Alaska is a unique US state because of its large size, geographically disparate population density, and physical distance from the contiguous United States. Here, we describe a pattern of SARS-CoV-2 variant emergence across Alaska reflective of these differences. Using genomic data, we found that in Alaska the Omicron sublineage BA.2.3 overtook BA.1.1 by the week of 2022-02-27, reaching 48.5% of sequenced cases. On the contrary in the contiguous United States, BA.1.1 dominated cases for longer, eventually being displaced by BA.2 sublineages other than BA.2.3. BA.2.3 only reached a prevalence of 10.9% in the contiguous United States. Using phylogenetics, we found evidence of potential origins of the two major clades of BA.2.3 in Alaska and with logistic regression estimated how it emerged and spread throughout the state. The combined evidence is suggestive of founder events in Alaska and is reflective of how Alaska’s unique dynamics influence the emergence of SARS-CoV-2 variants.

Identifiers

PMID35664999
PMCPMC9164444

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.