ArticleResearch square2022
Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of Diseases.
Chunyu Liu, Roby Joehanes, Jiantao Ma, Yuxuan Wang, Xianbang Sun, Amena Keshawarz, Meera Sooda, Tianxiao Huan, Shih-Jen Hwang, Helena Bui and 10 more
Abstract readPreprint
In one paragraphArticle in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors.
Chunyu LiuBoston University.
Roby JoehanesNational Institutes of Health.
Jiantao MaTufts University.
Yuxuan WangBoston University.
Xianbang SunBoston University.
Amena KeshawarzNational Institutes of Health.
Meera SoodaNational Institutes of Health.
Tianxiao HuanUniversity of Massachusetts Medical School.
Shih-Jen HwangNational Institutes of Health.
Helena BuiNational Institutes of Health.
Brandon TejadaNational Institutes of Health.
Peter J MunsonNational Institutes of Health.
Demirkale CumhurNational Institutes of Health.
Nancy L Heard-CostaFramingham Heart Study.
Achilleas N PitsillidesBoston University.
Gina M PelosoBoston University.
Michael FeoloNational Institutes of Health.
Nataliya SharopovaNational Institutes of Health.
Ramachandran S VasanFramingham Heart Study.
Daniel LevyFramingham Heart Study.
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MTrans-omic Analysis of Alcohol Consumption and its Relation to Cardiovascular DiseaseR01AA028263 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU, MA, JIANTAO · 2021 to 2025
$2.6MDietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201000011CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500011CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NIAAA NIH HHS R01 AA028263
6 · The paper itselfAbstract
To create a scientific resource of expression quantitative trail loci (eQTL), we conducted a genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) of DNA and gene expression levels from RNA sequencing (RNA-seq) of whole blood in 2622 participants in Framingham Heart Study. We identified 6,778,286
Identifiers
PMID35664994
PMCPMC9164515
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