Evidence map›Paper›PMID 35664801›Full record

ArticleFrontiers in oncology2022

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies

Marcin M Machnicki, Anna Rzepakowska, Joanna I Janowska, Monika Pepek, Alicja Krop, Katarzyna Pruszczyk, Piotr Stawinski, Malgorzata Rydzanicz, Jakub Grzybowski, Barbara Gornicka and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Mutations in epigenetic regulatorOncology research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Marcin M MachnickiDepartment of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland.
Anna RzepakowskaDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
Joanna I JanowskaDepartment of Immunology, Medical University of Warsaw, Warsaw, Poland.
Monika PepekDepartment of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland.
Alicja KropDepartment of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland.
Katarzyna PruszczykDepartment of Immunology, Medical University of Warsaw, Warsaw, Poland.
Piotr StawinskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Malgorzata RydzaniczDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Jakub GrzybowskiDepartment of Pathology, Medical University of Warsaw, Warsaw, Poland.
Barbara GornickaDepartment of Pathology, Medical University of Warsaw, Warsaw, Poland.
Maciej WnukDepartment of Biology, University of Rzeszow, Rzeszow, Poland.
Rafal PloskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Ewa Osuch-WojcikiewiczDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
Tomasz StoklosaDepartment of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLRzeszów University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypopharyngeal cancer is a poorly characterized type of head and neck squamous cell carcinoma (HNSCC) with bleak prognosis and only few studies focusing specifically on the genomic profile of this type of cancer. We performed molecular profiling of 48 HPV (Human Papilloma Virus)-negative tumor samples including 23 originating from the hypopharynx and 25 from the larynx using a targeted next-generation sequencing approach. Among genes previously described as significantly mutated,

Indexed as

head and neck squamous cell carcinoma (HNSCC)hypopharyngeal cancer (HPC)Kmt2claryngeal cancerMLL3mutational landscapenext-generation sequencing (NGS)

Identifiers

PMID35664801
PMCPMC9160230
OpenAlexW4280518024

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.