Evidence map›Paper›PMID 35664617›Full record

ArticleACS omega2022

Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug.

Akriti Kumari, Manvika Karnatak, Ajit Shankar Singh, Mohammad Hassam, Varun Rawat, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Mandeep Singh, Ved Prakash Verma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Akriti KumariDepartment of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India.
Manvika KarnatakDepartment of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India.
Ajit Shankar SinghDefence Materials and Stores Research Development Establishment, G.T. Road, Kanpur 208013, India.ORCID https://orcid.org/0000-0003-0629-6423
Mohammad HassamChemveda Life Sciences Pvt. Ltd., Hyderabad 500039, India.
Varun RawatAmity School of Applied Sciences, Amity University Haryana, Gurugram 122413, India.
Mohammad Shahidul IslamDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Abdullah Mohammed Al-MajidDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Mandeep SinghNuchem Sciences, Saint-Laurent, Quebec H4R2N6, Canada.ORCID https://orcid.org/0000-0003-0590-6197
Ved Prakash VermaDepartment of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India.ORCID https://orcid.org/0000-0003-2142-2459
Banasthali University · INKing Saud University · SADefence Materials and Stores Research and Development Establishment · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A mechanistic approach to understand the course of metabolism for synthetic 1,2,4-trioxanes, potent antimalarial compounds, to evaluate their bioavailability for antimalarial action has been studied in the present work. It is an important parameter to study the course of metabolism of a drug candidate molecule when administered via oral route during its journey from oral intake to its target site. From the pharmacokinetics point of view, it determines the bioavailability of an active drug or a prodrug at the target point. In this work, synthetic arylvinyl-1,2,4-trioxanes

Identifiers

PMID35664617
PMCPMC9161402
OpenAlexW4280572875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.