Evidence map›Paper›PMID 35664505›Full record

ArticleContemporary clinical trials communications2022

Enhancing Prolonged Exposure therapy for PTSD using physiological biomarker-driven technology.

Sudie E Back, Ron Acierno, Tanya C Saraiya, Bill Harley, Bethany Wangelin, Amber M Jarnecke, Lisa M McTeague, Delisa G Brown, Elizabeth Santa Ana, Alex O Rothbaum and 1 more

Open access · goldAbstract read
In one paragraph

Article in Contemporary clinical trials communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Building an Operational Definition of Grounding.Trauma, violence & abuse · 2026
    Review
  3. Article
  4. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sudie E BackDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Ron AciernoRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Tanya C SaraiyaDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Bill HarleyZeriscope, Inc., Charleston, SC, USA.
Bethany WangelinDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Amber M JarneckeDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Lisa M McTeagueDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Delisa G BrownDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Elizabeth Santa AnaDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Alex O RothbaumDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Robert J AdamsDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

DRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8M
Translational Research Training on Addictions for Racial/Ethnic MinoritiesR25DA035161 · NIDA · CITY COLLEGE OF NEW YORK · PI DENISE AIMEE HIEN, Lesia Monique Ruglass · 2013 to 2026
$4.4M
Intelligent Biometrics to Optimize Prolonged Exposure Treatment for PTSD (IB-PE)R43MH122045 · NIMH · ZERISCOPE, INC. · PI BACK, SUDIE E, HARLEY, WILLIAM · 2019 to 2020
$952k
NIDA NIH HHS R25 DA035161NIDA NIH HHS T32 DA007288NIMH NIH HHS R43 MH122045
6 · The paper itself

Abstract

Prolonged Exposure (PE) therapy is one of the most efficacious, evidence-based treatments for posttraumatic stress disorder (PTSD). A key component of PE involves in vivo exposures (IVEs) during which patients approach situations or activities in "real life" that are safe but avoided because they elicit a fear response. Despite their critical role in treatment, little research has focused on IVEs. This gap in knowledge is primarily due to the fact that IVEs are typically conducted by patients in between therapy sessions, leaving clinicians reliant upon patient self-report. This approach has numerous shortcomings, which the current study addresses by leveraging technology to develop an innovative device that allows for physiological, biomarker-driven, therapist-guided IVEs. The new system enables clinicians to virtually accompany patients during IVEs and provides real-time physiological (heart rate, skin conductance) and self-report (subjective units of distress) data that clinicians can use to modify the exposure and optimize therapeutic value. This Small Business Innovation Research (SBIR) Phase I project aims to: (1) integrate physiological sensors and live audio/visual streaming into a system for clinicians to guide patients during IVEs; (2) determine feasibility and acceptability of the system; and (3) conduct a pilot randomized clinical trial among veterans with PTSD (

Indexed as

CAPS-5, Clinician-Administered PTSD Scale for DSM-5DSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth EditionFDA, U.S. Food and Drug AdministrationIRB, Institutional Review BoardMilitaryMINI, Mini International Neuropsychiatric InterviewMUSC, Medical University of South CarolinaPCL-5, PTSD Checklist for DSM-5PhysiologyPosttraumatic stress disorderPTSDPTSD, posttraumatic stress disorderRCT, randomized controlled trialTechnologyU.S., United StatesVA, U.S. Department of Veterans AffairsVeterans

Identifiers

PMID35664505
PMCPMC9160482
OpenAlexW4281978742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.