ArticleFrontiers in psychiatry2022
The Psychopathology of Worthlessness in Depression.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Immersive virtual reality as an auxiliary intervention for college students with mild-to-moderate depressive symptoms: a pilot randomized controlled trial.Frontiers in psychology · 2026Trial
- Depression risk among college student witnesses to on-campus potentially traumatic events: the roles of bystanding, upstanding, and prosocial campus climate.Journal of behavioral medicine · 2026Article
- Trauma appraisals in the first month after sexual trauma differentially predict subsequent mental and physical health sequelae.Psychological trauma : theory, research, practice and policy · 2026Article
- Stressors and mental health in Chinese medical students: the mediating roles of positive and negative affect and moderating role of positive coping.BMC psychology · 2026Article
- The Association Between Contentment and Depressive Symptoms: Results From Three Panel Studies.Journal of clinical psychology · 2026Article
- Longitudinal validation of the GHQ-12 and PHQ-2 in Chilean social housing populations in urban regeneration contexts.Health and quality of life outcomes · 2026Article
- What plays beneath: mental health burden, personal resources, and treatment utilization among professional musicians and music students.Frontiers in psychology · 2026Article
- Multilayer network analysis of mental health symptoms in UK University students: association patterns of depression, loneliness, and suicidal ideation.Frontiers in psychiatry · 2026Article
- Associations between appetite loss and psychopathology as well as gender differences in adolescents with major depressive disorders.BMC psychiatry · 2025Article
- Family dynamics on mental health: a network analysis.Npj mental health research · 2025Article
- Anxious Traits Intensify the Impact of Depressive Symptoms on Stigma in People Living with HIV.Brain sciences · 2025Article
- Building Consensus on the Relevant Criteria to Screen for Depressive Symptoms Among Near-Centenarians and Centenarians: Modified e-Delphi Study.JMIR aging · 2025Article
- Associations between pulmonary function and depression: evidence from the CHARLS cohort 2015-2018.Frontiers in public health · 2025Article
- Developmental trajectory of guilt and shame during the transition to university.Frontiers in psychiatry · 2025Article
- Associations between appetite loss and clinical features as well as inflammatory cytokines in adolescents with major depressive disorder.Frontiers in psychiatry · 2025Article
- Graph analysis of guilt processing network highlights links with subclinical anxiety and self-blame.Social cognitive and affective neuroscience · 2024Article
- Cross-sectional association of food insecurity with loneliness in older adults: The role of sex, age, and psychosomatic factors.The journal of nutrition, health & aging · 2024Article
- The relationship between childhood psychological abuse and depression in college students: a moderated mediation model.BMC psychiatry · 2024Article
- Network Structure of Depressive Symptomatology in Elderly with Cognitive Impairment.Medicina (Kaunas, Lithuania) · 2024Article
- R425 first year student nurses 'experience of encounters with death of a patient during clinical placement.BMC nursing · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite common dissatisfaction with the syndromic heterogeneity of major depression, investigations into its symptom structure are scarce. Self-worthlessness/inadequacy is a distinctive and consistent symptom of major depression across cultures. Aims: We investigated whether self-worthlessness is associated with self-blaming attribution-related symptoms or is instead an expression of reduced positive feelings overall, as would be implied by reduced positive affect accounts of depression. Methods: 44,161 undergraduate students in Study 1, and 215 patients with current Major Depressive Disorder (MDD) and 237 age-matched healthy control participants in Study 2 completed the well-validated Symptom Check List-90. Depression-relevant items were used to construct regularized partial correlation networks with bootstrap estimates of network parameter variability. Results: Worthlessness co-occurred more strongly with other symptoms linked to self-blaming attributions (hopelessness, and self-blame), displaying a combined edge weight with these symptoms which was significantly stronger than the edge weight representing its connection with reduced positive emotion symptoms (such as reduced pleasure/interest/motivation, difference in edge weight sum in Study 1 = 2.95, in Study 2 = 1.64; 95% confidence intervals: Study 1: 2.6-3.4; Study 2: 0.02-3.5; Bonferroni-corrected Conclusions: This confirms the prediction of the revised learned helplessness model that worthlessness is most strongly linked to hopelessness and self-blame. In contrast, we did not find a strong and direct link between anhedonia items and a reduction in self-worth in either study. This supports worthlessness as a primary symptom rather than resulting from reduced positive affect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.