ArticleFrontiers in human neuroscience2022
Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Altered Temporospatial Variability of Dynamic Amplitude of Low-Frequency Fluctuation in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Reduced inter-subject functional connectivity during movies in autism: replicability across cross-national fMRI datasets.Molecular autism · 2026Article
- Investigating Resting-State Brain Activity in Adolescents with High-Functioning Autism Spectrum Disorder: Linking Fractional Amplitude of Low-Frequency Fluctuation to Clinical Symptoms.Journal of autism and developmental disorders · 2025Article
- Reduced local functional connectivity correlates with atypical performances in children with autism spectrum disorder.Brain imaging and behavior · 2025Article
- Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.Brain imaging and behavior · 2025Article
- Early identification of autism spectrum disorder in preschoolers by static and dynamic amplitude of low-frequency fluctuations features.Frontiers in human neuroscience · 2025Article
- Impaired effective functional connectivity in the social preference of children with autism spectrum disorder.Frontiers in neuroscience · 2024Article
- Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder.Behavioral and brain functions : BBF · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Abnormal brain function in ASD patients changes dynamically across developmental stages. However, no one has studied the brain function of prepubertal children with ASD. Prepuberty is an important stage for children's socialization. This study aimed to investigate alterations in local spontaneous brain activity in prepubertal boys with ASD. Materials and Methods: Measures of the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) acquired from resting-state functional magnetic resonance imaging (RS-fMRI) database, including 34 boys with ASD and 49 typically developing (TD) boys aged 7 to 10 years, were used to detect regional brain activity. Pearson correlation analyses were conducted on the relationship between abnormal ALFF and ReHo values and Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) scores. Results: In the ASD group, we found decreased ALFF in the left inferior parietal lobule (IPL) and decreased ReHo in the left lingual gyrus (LG), left superior temporal gyrus (STG), left middle occipital gyrus (MOG), and right cuneus ( Conclusion: Brain regions with functional abnormalities, including the left IPL, left LG, left STG, left MOG, and right cuneus may be crucial in the neuropathology of prepubertal boys with ASD. Furthermore, ReHo abnormalities in the left LG and left STG were correlated with sociality. These results will supplement the study of neural mechanisms in ASD at different developmental stages, and be helpful in exploring the neural mechanisms of prepubertal boys with ASD.
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