Evidence map›Paper›PMID 35664286›Full record

ArticleClinical kidney journal2022

Association between bone mineral density at different anatomical sites and both mortality and fracture risk in patients receiving renal replacement therapy: a longitudinal study.

David A Jaques, Scott Henderson, Andrew Davenport

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

David A JaquesDivision of Nephrology, Geneva University Hospitals, Geneva, Switzerland.
Scott HendersonUCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.
Andrew DavenportUCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.
University College London · GBUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The clinical utility of bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) is debated in end-stage kidney disease (ESKD). We assessed the ability of BMD measured at different anatomical sites to predict mortality and fracture risk in patients requiring renal replacement therapy (RRT). Methods: We reviewed all-cause mortality as well as incident hip and overall fracture risk in RRT patients who had BMD measured at the femoral neck, lumbar spine, arm, head, pelvis and total body as part of their routine follow-up between January 2004 and June 2012 at a single university centre. Results: A total of 588 patients were included. The median follow-up was 6.5 years, the mean age was 59.6 years and 57.9% were males. Femoral neck BMD (FNBMD) (normal/high versus low) was negatively associated with mortality in univariate and multivariate analyses ( Conclusions: BMD measured at the femoral neck is predictive of mortality in patients requiring RRT, regardless of modality. Low BMD might be a marker of global patient frailty rather than a direct causal factor in this setting. FNBMD is also a strong predictor of hip and any fracture risk in this population, regardless of bone turnover as assessed by PTH levels. FNBMD is thus an overall prognostic marker in patients requiring RRT.

Indexed as

bone mineral densitychronic kidney diseasedialysisfracturemortality

Identifiers

PMID35664286
PMCPMC9155216
OpenAlexW4210705690

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.