Evidence map›Paper›PMID 35664073›Full record

ArticleTheranostics2022

TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response.

Taewoo Kim, Jessica Johnston, Sonia Castillo-Lluva, Francisco J Cimas, Stephen Hamby, Cardiogenics Consortium*, Santiago Gonzalez-Moreno, Pedro Villarejo-Campos, Alison H Goodall, Guillermo Velasco and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  9. First reportedLeukemia research reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Taewoo KimDepartment of Infection, Immunity and Cardiovascular Diseases, University of Sheffield Medical School, Sheffield, S10 2RX, UK.
Jessica JohnstonDepartment of Infection, Immunity and Cardiovascular Diseases, University of Sheffield Medical School, Sheffield, S10 2RX, UK.
Sonia Castillo-LluvaDepartment of Biochemistry and Molecular Biology, Complutense University and Instituto de Investigación Sanitaria Clínico San Carlos (IdISSC), 28040, Madrid, Spain.
Francisco J CimasHospital Clínico San Carlos (HCSC), Instituto de Investigación Sanitaria Clínico San Carlos (IdISSC), Madrid and Universidad de Castilla La Mancha (UCLM), Albacete, Spain.
Stephen HambyDepartment of Cardiovascular Sciences, Glenfield Hospital, University of Leicester and Leicester NIHR Biomedical Research Centre, Leicester, UK.
Cardiogenics Consortium*
Santiago Gonzalez-MorenoMD Anderson Cancer Center Madrid, Madrid, Spain.
Pedro Villarejo-CamposHospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Alison H GoodallDepartment of Cardiovascular Sciences, Glenfield Hospital, University of Leicester and Leicester NIHR Biomedical Research Centre, Leicester, UK.
Guillermo VelascoDepartment of Biochemistry and Molecular Biology, Complutense University and Instituto de Investigación Sanitaria Clínico San Carlos (IdISSC), 28040, Madrid, Spain.
Alberto OcanaHospital Clínico San Carlos (HCSC), Instituto de Investigación Sanitaria Clínico San Carlos (IdISSC), Madrid and Universidad de Castilla La Mancha (UCLM), Albacete, Spain.
Munitta MuthanaDepartment of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, S10 2RX, UK.
Endre Kiss-TothDepartment of Infection, Immunity and Cardiovascular Diseases, University of Sheffield Medical School, Sheffield, S10 2RX, UK.
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESUniversity of Sheffield · GBHospital Universitario Fundación Jiménez Díaz · ESMD Anderson Cancer Center Madrid · ES

Funding

Cancer Research UK 24321Cancer Research UK C25574/A24321
6 · The paper itself

Abstract

Molecular mechanisms that regulate tumor-associated macrophage (TAM) phenotype and function are incompletely understood. The pseudokinase TRIB1 has been reported as a regulator of macrophage phenotypes, both in mouse and human systems.

Indexed as

Breast NeoplasmsTumor-Associated MacrophagesAnimalsCytokinesFemaleHumansInterleukin-15Intracellular Signaling Peptides and ProteinsMicePhenotypeProtein Serine-Threonine KinasesCytokinesInterleukin-15Intracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesTRIB1 protein, humanTrib1 protein, mouseBreast cancerinterleukin 15response to chemotherapyTRIB1tribblestumor associated macrophages

Identifiers

PMID35664073
PMCPMC9131267
OpenAlexW4285224363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.