Evidence map›Paper›PMID 35664057›Full record

ArticleTheranostics2022

Fibroblast activation protein α activatable theranostic pro-photosensitizer for accurate tumor imaging and highly-specific photodynamic therapy.

Yong Luo, Zishan Zeng, Ting Shan, Xiaoyu Xu, Jie Chen, Yuanfeng He, Tao Zhang, Zeqian Huang, Guihong Chai, Yanjuan Huang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Article
  7. FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review.Journal of biomedical physics & engineering · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yong LuoSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Zishan ZengSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Ting ShanSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Xiaoyu XuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Jie ChenSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Yuanfeng HeSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Tao ZhangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Zeqian HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Guihong ChaiSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Yanjuan HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Yanfang ZhaoKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. China.
Chunshun ZhaoSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of activatable photosensitizers (aPSs) responding to tumor-specific biomarkers for precision photodynamic therapy (PDT) is urgently required. Due to the unique proteolytic activity and highly restricted distribution of tumor-specific enzymes, enzyme activatable photosensitizers display superior selectivity.

Indexed as

Dermatitis, PhototoxicNeoplasmsPhotochemotherapyCell Line, TumorEndopeptidasesFibroblast Activation Protein AlphaGlutathioneHumansMembrane ProteinsPhotosensitizing AgentsPrecision MedicineTheranostic NanomedicineEndopeptidasesFibroblast Activation Protein AlphaGlutathioneMembrane ProteinsPhotosensitizing Agentsactivatable photosensitizerFibroblast activation protein αoxidative stress amplificationphotodynamic therapytumor imaging

Identifiers

PMID35664057
PMCPMC9131278
OpenAlexW4285178122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.