Evidence map›Paper›PMID 35664047›Full record

ArticleGlobal pediatric health2022

A Challenging Knowledge Gap: Estimating Modes of HIV Acquisition Among Adolescents Entering HIV Care During Adolescence.

John Humphrey, Miranda Triedman, Winstone Nyandiko, Edwin Sang, Emmanuel Kemboi, Marsha Alera, Vlad Novitsky, Akarsh Manne, Eslyne Jepkemboi, Millicent Orido and 4 more

Open access · goldAbstract read
In one paragraph

Article in Global pediatric health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

John HumphreyIndiana University, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0003-3156-1065
Miranda TriedmanBrown University, Providence, RI, USA.
Winstone NyandikoMoi University College of Health Sciences, Eldoret, Kenya.
Edwin SangAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Emmanuel KemboiAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Marsha AleraAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Vlad NovitskyBrown University, Providence, RI, USA.
Akarsh ManneBrown University, Providence, RI, USA.
Eslyne JepkemboiAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Millicent OridoAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Edith ApondiAcademic Model Providing Access to Healthcare, Eldoret, Kenya.
Rachel VreemanIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Kara Wools-KaloustianIndiana University, Indianapolis, IN, USA.
Rami KantorBrown University, Providence, RI, USA.ORCID https://orcid.org/0000-0003-3659-1108
AMPATH · KEBrown University · USIndiana University – Purdue University Indianapolis · USMoi University · KEIcahn School of Medicine at Mount Sinai · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
HIV Drug Resistance, Monitoring and TransmissionK24AI134359 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2018 to 2026
$1.3M
NCATS NIH HHS UL1 TR002529NIAID NIH HHS K24 AI134359NIAID NIH HHS P30 AI042853
6 · The paper itself

Abstract

Characterizing HIV acquisition modes among adolescents with HIV (AHIV) enrolling in care during adolescence is a challenging gap that impacts differential interventions. We explored whether primary data collection with targeted questionnaires may address this gap and improve understanding of risk factors and perceptions about adolescents' HIV acquisition, in Kenyan AHIV entering care at ≥10 years, and their mothers with HIV (MHIV). Clinical data were derived through chart review. Among 1073 AHIV in care, only 26 (2%) met eligibility criteria of being ≥10 years at care enrollment, disclosed to, and with living MHIV. Among 18/26 AHIV-MHIV dyads enrolled (median age of AHIV 14 years), none had documented HIV acquisition modes. Data suggested perinatal infection in 17/18 AHIV, with 1 reported non-perinatal acquisition risk factor, and some discordance between adolescent-mother perceptions of HIV acquisition. In this difficult-to-enroll, vulnerable population of AHIV-MHIV dyads, primary data collection can enhance understanding of AHIV acquisition modes.

Indexed as

adolescentHIVHIV transmission modelate care entrymother-to-child transmission

Identifiers

PMID35664047
PMCPMC9160889
OpenAlexW4285147826

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.