Evidence map›Paper›PMID 35663993›Full record

ArticleFrontiers in immunology2022

Longitudinal Dynamics of Cellular Responses in Recovered COVID-19 Patients.

Meng-Li Cheng, Hui-Ying Liu, Chao Zhou, Rui-Ting Li, Jing Zheng, Yan-Hong Qin, Ning Yang, Yue Zhang, Juan-Juan Huang, Zhu Zhu and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Meng-Li ChengDepartment of Pathogenobiology, The Key Laboratory of Zoonosis Research, Chinese Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Hui-Ying LiuDepartment of Respiratory and Critical Care Diseases, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Chao ZhouDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Rui-Ting LiDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Jing ZhengDepartment of Respiratory and Critical Care Diseases, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Yan-Hong QinDepartment of Respiratory and Critical Care Diseases, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Ning YangDepartment of Respiratory and Critical Care Diseases, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Yue ZhangDepartment of Respiratory and Critical Care Diseases, The Fifth Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Juan-Juan HuangDepartment of Pathogenobiology, The Key Laboratory of Zoonosis Research, Chinese Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Zhu ZhuDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Qing-Yu MengDepartment of Pathogenobiology, The Key Laboratory of Zoonosis Research, Chinese Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Guo-Qing WangDepartment of Pathogenobiology, The Key Laboratory of Zoonosis Research, Chinese Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Hui ZhaoDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Yun ChenDepartment of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing, China.
Chang-Qing BaiDepartment of Respiratory and Critical Care Medicine, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China.
Cheng-Feng QinDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
Fan LiDepartment of Pathogenobiology, The Key Laboratory of Zoonosis Research, Chinese Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Chinese People's Liberation Army · CNJilin University · CNAcademy of Military Medical Sciences · CNInstitute of Microbiology · CNNanjing Medical University · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safe and effective vaccines and therapeutics based on the understanding of antiviral immunity are urgently needed to end the COVID-19 pandemic. However, the understanding of these immune responses, especially cellular immune responses to SARS-CoV-2 infection, is limited. Here, we conducted a cohort study of COVID-19 patients who were followed and had blood collected to characterize the longitudinal dynamics of their cellular immune responses. Compared with healthy controls, the percentage of activation of SARS-CoV-2 S/N-specific T cells in recovered patients was significantly higher. And the activation percentage of S/N-specific CD8

Indexed as

COVID-19CD8-Positive T-LymphocytesCohort StudiesCOVID-19 VaccinesHumansImmunity, CellularInterleukin-2PandemicsSARS-CoV-2COVID-19 VaccinesInterleukin-2cellular immunityCOVID-19interferonSARS-CoV-2Th1 cytokines

Identifiers

PMID35663993
PMCPMC9161166
OpenAlexW4280632487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.