Evidence map›Paper›PMID 35663985›Full record

ArticleFrontiers in immunology2022

The Hypothiocyanite and Amantadine Combination Treatment Prevents Lethal Influenza A Virus Infection in Mice.

Nuha Milad Ashtiwi, Demba Sarr, Tamás Nagy, Z Beau Reneer, Ralph A Tripp, Balázs Rada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nuha Milad AshtiwiDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Demba SarrDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Tamás NagyDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Z Beau ReneerDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Ralph A TrippDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Balázs RadaDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Neutrophil extracellular traps in cystic fibrosisR01HL136707 · NHLBI · UNIVERSITY OF GEORGIA · PI RADA, BALAZS · 2018 to 2021
$2.6M
Dual oxidase and lactoperoxidase in influenza infectionR01AI146857 · NIAID · UNIVERSITY OF GEORGIA · PI RADA, BALAZS, TRIPP, RALPH A · 2020 to 2024
$1.9M
NHLBI NIH HHS R01 HL136707NIAID NIH HHS R01 AI146857
6 · The paper itself

Abstract

The influenza virus has a large clinical burden and is associated with significant mortality and morbidity. The development of effective drugs for the treatment or prevention of influenza is important in order to reduce its impact. Adamantanes and neuraminidase inhibitors are two classes of anti-influenza drugs in which resistance has developed; thus, there is an urgent need to explore new therapeutic options. Boosting antiviral innate immune mechanisms in the airways represents an attractive approach. Hypothiocyanite (OSCN

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanAmantadineAnimalsAntiviral AgentsHumansInfluenza A Virus, H3N2 SubtypeMiceThiocyanatesAmantadineAntiviral Agentshypothiocyanite ionThiocyanatesamantadinehypothiocyaniteinfluenzalactoperoxidaselethaltreatment

Identifiers

PMID35663985
PMCPMC9159274
OpenAlexW4280577094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.