Evidence map›Paper›PMID 35663973›Full record

ArticleFrontiers in immunology2022

Phosphatidylcholine Liposomes Down-Modulate CD4 Expression Reducing HIV Entry in Human Type-1 Macrophages.

Federica De Santis, Ana Borrajo Lopez, Sara Virtuoso, Noemi Poerio, Patrizia Saccomandi, Tommaso Olimpieri, Leonardo Duca, Lucia Henrici De Angelis, Katia Aquilano, Marco Maria D'Andrea and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Federica De SantisDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Ana Borrajo LopezDipartimento di Medicina Sperimentale, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Sara VirtuosoCentro Nazionale per la ricerca su HIV/AIDS, Istituto Superiore di Sanità, Roma, Italy.
Noemi PoerioDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Patrizia SaccomandiDipartimento di Medicina Sperimentale, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Tommaso OlimpieriDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Leonardo DucaDipartimento di Medicina Sperimentale, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Lucia Henrici De AngelisDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Katia AquilanoDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Marco Maria D'AndreaDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Stefano AquaroDipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Rende, Italy.
Alessandra BorsettiCentro Nazionale per la ricerca su HIV/AIDS, Istituto Superiore di Sanità, Roma, Italy.
Francesca Ceccherini-SilbersteinDipartimento di Medicina Sperimentale, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
Maurizio FrazianoDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Roma, Italy.
University of Rome Tor Vergata · ITIstituto Superiore di Sanità · ITUniversity of Calabria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A strategy adopted to combat human immunodeficiency virus type-1 (HIV-1) infection is based on interfering with virus entry into target cells. In this study, we found that phosphatidylcholine (PC) liposomes reduced the expression of the CD4 receptor in human primary type-1 macrophages but not in CD4

Indexed as

HIV-1HIV InfectionsCD4 AntigensCD4-Positive T-LymphocytesHumansLiposomesMacrophagesPhosphatidylcholinesSerineCD4 AntigensLiposomesPhosphatidylcholinesSerineHIV entryhost-directed therapyliposomemacrophagephosphatidylcholine

Identifiers

PMID35663973
PMCPMC9160374
OpenAlexW4280637070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.