Evidence map›Paper›PMID 35663826›Full record

ArticleFrontiers in signal processing2022

Modulation of Beta Oscillations in the Pallidum During Externally Cued Gait.

Chiahao Lu, Sommer L Amundsen-Huffmaster, Kenneth H Louie, Matthew N Petrucci, Tara Palnitkar, Remi Patriat, Noam Harel, Michael C Park, Jerrold L Vitek, Colum D MacKinnon and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in signal processing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chiahao LuDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Sommer L Amundsen-HuffmasterDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Kenneth H LouieDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.
Matthew N PetrucciDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Tara PalnitkarDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Remi PatriatDepartment of Radiology, University of Minnesota, Minneapolis, MN, United States.
Noam HarelDepartment of Radiology, University of Minnesota, Minneapolis, MN, United States.
Michael C ParkDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2021 to 2025
$11.3M
NCATS NIH HHS UL1 TR000114NINDS NIH HHS P50 NS123109
6 · The paper itself

Abstract

Freezing of gait (FOG) is a particularly debilitating symptom of Parkinson's disease (PD) and is often refractory to treatment. A striking feature of FOG is that external sensory cues can be used to overcome freezing and improve gait. Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) and globus pallidus (GP) show that beta-band power modulates with gait phase. In the STN, beta-band oscillations are modulated by external cues, but it is unknown if this relationship holds in the globus pallidus (GP). Here we report LFP data recorded from the left GP, using a Medtronic PC + S device, in a 68-year-old man with PD and FOG during treadmill walking. A "stepping stone" task was used during which stepping was cued using visual targets of constant color or targets that unpredictably changed color, requiring a step length adjustment. Gait performance was quantified using measures of treadmill ground reaction forces and center of pressure and body kinematics from video monitoring. Beta-band power (12-30 Hz) and number of freezing episodes were measured. Cues which unpredictably changed color improved FOG more than conventional cues and were associated with greater modulation of beta-band power in phase with gait. This preliminary finding suggests that cueing-induced improvement of FOG may relate to beta-band modulation.

Indexed as

external cueingfreezing of gait (FOG)gait disorderLocal field potential (LFP)Parkinson’s disease

Identifiers

PMID35663826
PMCPMC9164277
OpenAlexW4285743679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.