Evidence map›Paper›PMID 35663656›Full record

ArticleCureus2022

Effect of Bone Morphogenetic Protein-2 (BMP-2)/Hydroxyapatite/In Situ-Formed Hyaluronan Hydrogel Composites on Bone Formation in a Murine Model of Posterolateral Lumbar Fusion.

Akiyoshi Kuroda, Wataru Saito, Gen Inoue, Masayuki Miyagi, Shintaro Shoji, Hiroyuki Sekiguchi, Masashi Takaso, Kentaro Uchida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akiyoshi KurodaDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Wataru SaitoDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Gen InoueDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Masayuki MiyagiDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Shintaro ShojiDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Hiroyuki SekiguchiDepartment of Orthopaedics, Medical Sciences Research Institute, Shonan University, Chigasaki, JPN.
Masashi TakasoDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.
Kentaro UchidaDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several types of calcium phosphate (CaP) biomaterial carriers have been designed to deliver bone morphogenetic protein-2 (BMP-2) to augment spinal fusion in spinal surgery. Here, we evaluated an in situ-formed hydrogel (IFH) constructed from hyaluronan (IFH-HA) combined with a BMP2/hydroxyapatite (HAP) composite in bone formation in a murine model of posterolateral lumbar fusion (PLF). HAP was submerged in HA-tyramine (TA) polymer solution containing horseradish peroxidase (HRP) and 2 µg BMP-2 (BMP2/HA-TA/HRP solution). H

Indexed as

bone morphogenetic protein-2hyaluronanhydroxyapatitein situ-formed hydrogelposterolateral lumbar fusion

Identifiers

PMID35663656
PMCPMC9152467

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.