ArticleFrontiers in aging neuroscience2022
Concurrent Structural and Functional Patterns in Patients With Amnestic Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Altered dynamic functional connectivity of the language network associated with electronegative L5 in patients with mild cognitive impairment.GeroScience · 2026Article
- Brain functional alterations in early stage of coal workers' pneumoconiosis with alcoholism: insights from a resting-state fMRI investigation.Frontiers in neuroscience · 2025Article
- Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis.Brain imaging and behavior · 2024Article
- The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Self-supervised multimodal learning for group inferences from MRI data: Discovering disorder-relevant brain regions and multimodal links.NeuroImage · 2024Article
- Elevated serum platelet count inhibits the effects of brain functional changes on cognitive function in patients with mild cognitive impairment: A resting-state functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2023Article
- Textural features reflecting local activity of the hippocampus improve the diagnosis of Alzheimer's disease and amnestic mild cognitive impairment: A radiomics study based on functional magnetic resonance imaging.Frontiers in neuroscience · 2022Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amnestic mild cognitive impairment (aMCI) is a clinical subtype of MCI, which is known to have a high risk of developing Alzheimer's disease (AD). Although neuroimaging studies have reported brain abnormalities in patients with aMCI, concurrent structural and functional patterns in patients with aMCI were still unclear. In this study, we combined voxel-based morphometry (VBM), amplitude of low-frequency fluctuations (ALFFs), regional homogeneity (Reho), and resting-state functional connectivity (RSFC) approaches to explore concurrent structural and functional alterations in patients with aMCI. We found that, compared with healthy controls (HCs), both ALFF and Reho were decreased in the right superior frontal gyrus (SFG_R) and right middle frontal gyrus (MFG_R) of patients with aMCI, and both gray matter volume (GMV) and Reho were decreased in the left inferior frontal gyrus (IFG_L) of patients with aMCI. Furthermore, we took these overlapping clusters from VBM, ALFF, and Reho analyses as seed regions to analyze RSFC. We found that, compared with HCs, patients with aMCI had decreased RSFC between SFG_R and the right temporal lobe (subgyral) (TL_R), the MFG_R seed and left superior temporal gyrus (STG_L), left inferior parietal lobule (IPL_L), and right anterior cingulate cortex (ACC_R), the IFG_L seed and left precentral gyrus (PRG_L), left cingulate gyrus (CG_L), and IPL_L. These findings highlighted shared imaging features in structural and functional magnetic resonance imaging (MRI), suggesting that SFG_R, MFG_R, and IFG_L may play a major role in the pathophysiology of aMCI, which might be useful to better understand the underlying neural mechanisms of aMCI and AD.
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