ArticleEngineering in life sciences2022
Study on the development and integration of 3D-printed optics in small-scale productions of single-use cultivation vessels.
Article in Engineering in life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Pulse Driven Injection in an Additive-Manufactured Microchannel for Rapid Mixing of Stratified Concurrent Flow and On-Demand Droplet Generation.Micromachines · 2026Article
- Optimization of the angle for scattered light measurements in 3D-printed cultivation vessels.Analytical and bioanalytical chemistry · 2025Article
- Investigation and evaluation of a 3D-printed optical modified cultivation vessel for improved scattered light measurement of biotechnologically relevant organisms.Engineering in life sciences · 2023Article
- Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring.Bioengineering (Basel, Switzerland) · 2022Review
- Study on the development and integration of 3D-printed optics in small-scale productions of single-use cultivation vessels.Engineering in life sciences · 2022Article
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Authors and funding
4 authors.
Funding
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Abstract
Integrating optical sensors and 3D-printed optics into single-use (SU) cultivation vessels for customized, tailor-made equipment could be a next big step in the bioreactor and screening platform development enabling online bioprocess monitoring. Many different parameters such as pH, oxygen, carbon dioxide and optical density (OD) can be monitored more easily using online measuring instruments compared to offline sampling. Space-saving integrated sensors in combination with adapted optics such as prisms open up vastly new possibilities to precisely guide light through SU vessels. This study examines how optical prisms can be 3D-printed with a 3D-inkjet printer, modified and then evaluated in a custom made optical bench. The prisms are coated or bonded with thin cover glasses. For the examination of reflectance performance and conformity prisms are compared on the basis of measured characteristics of a conventional glass prism. In addition, the most efficient and reproducible prism geometry and modification technique is applied to a customized 3D-printed cultivation vessel. The vessel is evaluated on a commercial sensor-platform, a shake flask reader (SFR) vario, to investigate its sensing-characteristics while monitoring scattered light with the turbidity standard formazine and a cell suspension of
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