ArticleFrontiers in cellular and infection microbiology2022
Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection With
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Single-cell transcriptomic atlas uncovers immune/structural lineage remodeling and fibrosis inVirulence · 2026Article
- Genomic and functional approaches point to potential determinants of neonatalMicrobiology spectrum · 2026Article
- Review
- Serum iron is associated with the prognosis in sepsis based on a large-scale database.BMC infectious diseases · 2026Article
- Modulating drug response through the gut microbiome: pathways to precision therapy.Archives of microbiology · 2026Review
- ChronicInternational journal of molecular sciences · 2025Article
- The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Proteomic analysis of meropenem-induced outer membrane vesicles released by carbapenem-resistantMicrobiology spectrum · 2024Article
- Human airway epithelium controlsFrontiers in immunology · 2024Article
- Article
- Advances in Ferritin Physiology and Possible Implications in Bacterial Infection.International journal of molecular sciences · 2023Review
- Article
- Availability of Ferritin-Bound Iron to Enterobacteriaceae.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Pneumonia is often elicited by bacteria and can be associated with a severe clinical course, respiratory failure and the need for mechanical ventilation. In the alveolus, type-2-alveolar-epithelial-cells (AECII) contribute to innate immune functions. We hypothesized that AECII actively adapt cellular iron homeostasis to restrict this essential nutrient from invading pathogens - a defense strategy termed 'nutritional immunity', hitherto mainly demonstrated for myeloid cells. Methods: We established an Results: Both, Conclusion: AECII-derived A549 cells show pathogen-specific innate immune functions and adapt their iron handling in response to infection. The differential regulation of iron transporters depends on the preferential intra- or extracellular localization of the pathogen and likely aims at limiting bacterial iron availability.
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