Evidence map›Paper›PMID 35663420›Full record

ReviewInternational journal of hematologic oncology2022

Adhesion molecules in multiple myeloma oncogenesis and targeted therapy.

Maroun Bou Zerdan, Lewis Nasr, Joseph Kassab, Ludovic Saba, Myriam Ghossein, Marita Yaghi, Barbara Dominguez, Chakra P Chaulagain

Open access · goldAbstract readReview
In one paragraph

Review in International journal of hematologic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Multiple myeloma.Nature reviews. Disease primers · 2024
    Review
  10. Review
  11. Article
  12. Lenalidomide use in multiple myeloma (Review).Molecular and clinical oncology · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maroun Bou ZerdanDepartment of Hematology-Oncology, Myeloma & Amyloidosis Program, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL 33331, USA.ORCID https://orcid.org/0000-0002-9229-3079
Lewis NasrSaint-Joseph University, Faculty of Medicine, Beirut, Lebanon.
Joseph KassabSaint-Joseph University, Faculty of Medicine, Beirut, Lebanon.
Ludovic SabaSaint-Joseph University, Faculty of Medicine, Beirut, Lebanon.
Myriam GhosseinDepartment of Medicine & Medical Sciences, University of Balamand, Balamand, Lebanon.
Marita YaghiDepartment of Hematology-Oncology, Myeloma & Amyloidosis Program, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL 33331, USA.
Barbara DominguezDepartment of Hematology-Oncology, Myeloma & Amyloidosis Program, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL 33331, USA.
Chakra P ChaulagainDepartment of Hematology-Oncology, Myeloma & Amyloidosis Program, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL 33331, USA.ORCID https://orcid.org/0000-0002-4641-2217
Cleveland Clinic Florida · USSaint Joseph University · LBUniversity of Balamand · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Every day we march closer to finding the cure for multiple myeloma. The myeloma cells inflict their damage through specialized cellular meshwork and cytokines system. Implicit in these interactions are cellular adhesion molecules and their regulators which include but are not limited to integrins and syndecan-1/CD138, immunoglobulin superfamily cell adhesion molecules, such as CD44, cadherins such as N-cadherin, and selectins, such as E-selectin. Several adhesion molecules are respectively involved in myelomagenesis such as in the transition from the precursor disorder monoclonal gammopathy of undetermined significance to indolent asymptomatic multiple myeloma (smoldering myeloma) then to active multiple myeloma or primary plasma cell leukemia, and in the pathological manifestations of multiple myeloma.

Indexed as

bone marrow microenvironmentcellular adhesion moleculesdrug resistancemonoclonal antibodymultiple myelomatargeted therapies

Identifiers

PMID35663420
PMCPMC9136637
OpenAlexW4224995871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.