Evidence map›Paper›PMID 35663383›Full record

ArticleBrain communications2022

Coupling cognitive and brainstem dysfunction in multiple sclerosis-related chronic neuropathic limb pain.

Peter Foley, Yazhuo Kong, Ramune Dirvanskiene, Maria Valdes-Hernandez, Matteo Bastiani, Jonathan Murnane, Robin Sellar, Neil Roberts, Cyril Pernet, Christopher Weir and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Peter FoleyAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0001-7039-2976
Yazhuo KongCAS Key Laboratory of Behavioural Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-8249-4723
Ramune DirvanskieneAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Maria Valdes-HernandezDementia Research Institute, University of Edinburgh, Edinburgh, UK.
Matteo BastianiSir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Jonathan MurnaneClinical Research Imaging Centre, Edinburgh University, Edinburgh, UK.
Robin SellarCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Neil RobertsClinical Research Imaging Centre, Edinburgh University, Edinburgh, UK.ORCID https://orcid.org/0000-0001-5538-8653
Cyril PernetCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-4010-4632
Christopher WeirEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Thomas BakSchool of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.
Lesley ColvinDivision of Population Health and Genomics, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0002-1563-8600
Siddharthan ChandranAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Marie FallonDepartment of Palliative Medicine, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0001-9214-0091
Irene TraceyWellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
University of Edinburgh · GBUK Dementia Research Institute · GBInstitute of Psychology, Chinese Academy of Sciences · CNJohn Radcliffe Hospital · GBUniversity of Dundee · GBUniversity of Nottingham · GB

Funding

Medical Research Council MC_EX_MR/N50192X/1Wellcome Trust
6 · The paper itself

Abstract

Chronic pain in multiple sclerosis is common and difficult to treat. Its mechanisms remain incompletely understood. Dysfunction of the descending pain modulatory system is known to contribute to human chronic pain conditions. However, it is not clear how alterations in executive function influence this network, despite healthy volunteer studies linking function of the descending pain modulatory system, to cognition. In adults with multiple sclerosis-associated chronic neuropathic limb pain, compared to those without pain, we hypothesized altered functional connectivity of the descending pain modulatory system, coupled to executive dysfunction. Specifically we hypothesized reduced mental flexibility, because of potential importance in stimulus reappraisal. To investigate these hypotheses, we conducted a case-control cross-sectional study of 47 adults with relapsing remitting multiple sclerosis (31 with chronic neuropathic limb pain, 16 without pain), employing clinical, neuropsychological, structural, and functional MRI measures. We measured brain lesions and atrophy affecting descending pain modulatory system structures. Both cognitive and affective dysfunctions were confirmed in the chronic neuropathic limb pain group, including reduced mental flexibility (Delis Kaplan Executive Function System card sorting tests

Indexed as

brainstemcognitionmultiple sclerosisneuropathicpain

Identifiers

PMID35663383
PMCPMC9155950
OpenAlexW4280614322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.