Evidence map›Paper›PMID 35663380›Full record

ArticleBrain communications2022

Histologic lesion type correlates of magnetic resonance imaging biomarkers in four-repeat tauopathies.

Arenn F Carlos, Nirubol Tosakulwong, Stephen D Weigand, Marina Buciuc, Farwa Ali, Heather M Clark, Hugo Botha, Rene L Utianski, Mary M Machulda, Christopher G Schwarz and 7 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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  9. The Role of Clinical Assessment in the Era of Biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Arenn F CarlosDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-2100-5033
Nirubol TosakulwongDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Stephen D WeigandDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Marina BuciucDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0003-4826-5430
Farwa AliDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Heather M ClarkDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0003-4390-685X
Rene L UtianskiDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Mary M MachuldaDepartment of Psychology and Psychiatry, Mayo Clinic, Rochester, MN 55905, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Robert I ReidDepartment of Psychology and Psychiatry, Mayo Clinic, Rochester, MN 55905, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-7916-622X
J Eric AhlskogDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID https://orcid.org/0000-0001-7189-7917
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0003-2930-8634
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-6914-1563
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
The neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s diseaseRF1NS112153 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2021 to 2021
$1.2M
NIDCD NIH HHS R01 DC010367NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942NINDS NIH HHS R01 NS089757NINDS NIH HHS RF1 NS112153
6 · The paper itself

Abstract

Primary four-repeat tauopathies are characterized by depositions of the four-repeat isoform of the microtubule binding protein, tau. The two most common sporadic four-repeat tauopathies are progressive supranuclear palsy and corticobasal degeneration. Because tau PET tracers exhibit poor binding affinity to four-repeat pathology, determining how well

Indexed as

4R tauopathybiomarkersDTItau lesionsvolumetric MRI

Identifiers

PMID35663380
PMCPMC9155234
OpenAlexW4225918925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.