ArticleFrontiers in endocrinology2022
Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Double Burden of Malnutrition Prevalence in Pregnant Women: Systematic Review and Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Pooled it
- The association between ultra-processed food and common pregnancy adverse outcomes: a dose-response systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- One-step versus two-step screening for diagnosis of gestational diabetes mellitus in Iranian population: A randomized community trial.Frontiers in endocrinology · 2022Trial
- Pre-pregnancy body mass index and neonatal body weight in Japanese women with gestational diabetes mellitus: Hamamatsu GRACE Study 1.Endocrine journal · 2026Article
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- Article
- Trends and Projections of the Prevalence of Diabetes Mellitus in Pregnancy and Fetal-Neonatal Metabolic Disorders, 2010-2035: A Nationwide Population-Based Study from Hungary.Journal of clinical medicine · 2025Article
- The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies.Current diabetes reports · 2025Review
- Metabolic Phenotypes of Women with Gestational Diabetes Mellitus Affect the Risk of Adverse Pregnancy Outcomes.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Article
- Identification and validation of gestational diabetes subgroups by data-driven cluster analysis.Diabetologia · 2024Article
- Insulin aspart plus high-dose vitamin D supplementation for gestational diabetes mellitus: analysis of efficacy and risk factors for maternal and infant outcomes.American journal of translational research · 2024Article
- The association between blood groups, Rhesus factors, body mass index and obesity among pregnant women at Gadarif Maternity Hospital, Eastern Sudan.BMC pregnancy and childbirth · 2023Article
- Continuous glucose monitoring-derived glycemic metrics and adverse pregnancy outcomes among women with gestational diabetes: a prospective cohort study.The Lancet regional health. Western Pacific · 2023Article
- Characteristics of the oral glucose tolerance test in women with different pre-pregnancy body mass index and the effect of gestational diabetes mellitus on twin pregnancy outcomes.Clinics (Sao Paulo, Brazil) · 2023Article
- New Developments, Challenges and Open Questions in Diagnosis and Treatment of Gestational Diabetes Mellitus.Journal of clinical medicine · 2022Article
- Editorial: Research Topic for Frontiers in Endocrinology (Obesity): Fetal Origin of Obesity and Diabetes.Frontiers in endocrinology · 2022Article
- Research advances in gestational, neonatal diabetes mellitus and metabolic disorders.Frontiers in endocrinology · 2022Article
- Comparison of perinatal outcomes of women with gestational diabetes mellitus according to type of treatment for glycemic control.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We aim to evaluate the impact of prepregnancy overweight on treatment modalities of Gestational Diabetes Mellitus (GDM). We assessed the association of increased pregravid Body Mass Index (BMI) with dosing of basal and rapid acting insulin as well as pregnancy outcome. Methods: We included 509 gestational diabetic women (normal weight: 200, overweight: 157, obese: 152), attending the pregnancy outpatient clinic at the Department of Obstetrics and Gynecology, Medical University of Vienna, in this retrospective study. We used a prospectively compiled database to assess patient characteristics, treatment approaches - particularly maximum doses of basal and rapid acting insulin or metformin - and pregnancy outcome. Results: Increased BMI was associated with the need of glucose lowering medication (odds ratio (OR): 1.08 for the increase of 1 kg/m² BMI, 95%CI 1.05-1.11, p<0.001). Mothers with pregestational obesity received the highest amount of insulin. Metformin was more often used in patients with obesity who also required higher daily doses. Maternal BMI was associated with increased risk of cesarean section (OR 1.04, 95%CI 1.01-1.07, p<0.001) and delivering large for gestational age offspring (OR 1.09, 95%CI 1.04-1.13, p<0.001). Birthweight percentiles were highest in patients with obesity who required glucose lowering therapy. Conclusions: Treatment modalities and outcome in GDM pregnancies are closely related to the extent of maternal BMI. Patients with obesity required glucose lowering medication more often and were at higher risk of adverse pregnancy outcomes. It is crucial to further explore the underlying pathophysiologic mechanisms to optimize clinical management and individual treatment approaches.
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Registered trials
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