Evidence map›Paper›PMID 35663263›Full record

ReviewFrontiers in molecular neuroscience2022

Non-invasive Brain Stimulation for Central Neuropathic Pain.

Qi-Hao Yang, Yong-Hui Zhang, Shu-Hao Du, Yu-Chen Wang, Yu Fang, Xue-Qiang Wang

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05645003 (Effect of Repetative Transcranial Magnetic Stimulation Therapy on Neuropathic Pain in Patients With Spinal Cord Injury), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05645003 narecruitingnot on this map

Effect of Repetative Transcranial Magnetic Stimulation Therapy on Neuropathic Pain in Patients With Spinal Cord Injury

TypeinterventionalSponsorAfyonkarahisar Health Sciences UniversityRan2022 to 2026Enrolled60ConditionsSpinal Cord Injuries, Neuropathic Pain, Neurological Diseases or ConditionsArmsHigh-frequency real-time rTMS protocol, Sham rTMS Protocol
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Pooled it
  3. Resonance massage tool effects in non-migraine headache management.Journal of oral & facial pain and headache · 2025
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qi-Hao YangDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Yong-Hui ZhangDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Shu-Hao DuDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Yu-Chen WangDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Yu FangSchool of Mechanical and Automotive Engineering, Shanghai University of Engineering Science, Shanghai, China.
Xue-Qiang WangDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Shanghai University of Sport · CNShanghai University of Engineering Science · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The research and clinical application of the noninvasive brain stimulation (NIBS) technique in the treatment of neuropathic pain (NP) are increasing. In this review article, we outline the effectiveness and limitations of the NIBS approach in treating common central neuropathic pain (CNP). This article summarizes the research progress of NIBS in the treatment of different CNPs and describes the effects and mechanisms of these methods on different CNPs. Repetitive transcranial magnetic stimulation (rTMS) analgesic research has been relatively mature and applied to a variety of CNP treatments. But the optimal stimulation targets, stimulation intensity, and stimulation time of transcranial direct current stimulation (tDCS) for each type of CNP are still difficult to identify. The analgesic mechanism of rTMS is similar to that of tDCS, both of which change cortical excitability and synaptic plasticity, regulate the release of related neurotransmitters and affect the structural and functional connections of brain regions associated with pain processing and regulation. Some deficiencies are found in current NIBS relevant studies, such as small sample size, difficulty to avoid placebo effect, and insufficient research on analgesia mechanism. Future research should gradually carry out large-scale, multicenter studies to test the stability and reliability of the analgesic effects of NIBS.

Indexed as

analgesic effectsanalgesic mechanismcentral neuropathic painrTMStDCS

Identifiers

PMID35663263
PMCPMC9162797
OpenAlexW4280514555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.