Evidence map›Paper›PMID 35663229›Full record

ArticleMolecular therapy oncolytics2022

miR-15a and miR-15b modulate natural killer and CD8

Anup S Pathania, Philip Prathipati, Omalla A Olwenyi, Srinivas Chava, Oghenetejiri V Smith, Subash C Gupta, Nagendra K Chaturvedi, Siddappa N Byrareddy, Don W Coulter, Kishore B Challagundla

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  8. FOXJ3, a novel tumor suppressor in neuroblastoma.Molecular therapy. Oncology · 2025
    Article
  9. Article
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  11. The Role of Deregulated MicroRNAs in Immune Cells of Sjögren's Disease.International journal of general medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Anup S PathaniaDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Philip PrathipatiLaboratory of Bioinformatics, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki City, Osaka 567-0085, Japan.
Omalla A OlwenyiDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Srinivas ChavaDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Oghenetejiri V SmithDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Subash C GuptaDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.
Nagendra K ChaturvediDepartment of Pediatrics, Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Siddappa N ByrareddyDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Don W CoulterDepartment of Pediatrics, Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kishore B ChallagundlaDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USBanaras Hindu University · INNational Institute of Biomedical Innovation, Health and Nutrition · JP

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Amy M Overby · 1985 to 2026
$55.0M
Exosomic microRNAs and drug resistance in AML tumor microenvironmentK22CA197074 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHALLAGUNDLA, KISHORE B. · 2016 to 2018
$465k
NCI NIH HHS K22 CA197074NCI NIH HHS P30 CA036727
6 · The paper itself

Abstract

Neuroblastoma (NB) is an enigmatic and deadliest pediatric cancer to treat. The major obstacles to the effective immunotherapy treatments in NB are defective immune cells and the immune evasion tactics deployed by the tumor cells and the stromal microenvironment. Nervous system development during embryonic and pediatric stages is critically mediated by non-coding RNAs such as micro RNAs (miR). Hence, we explored the role of miRs in

Indexed as

anti-tumor immune responseCD8+T cellschemotherapymiRNAsnatural killer cellsneuroblastomapatient-derived xenograftsPD-L1survival

Identifiers

PMID35663229
PMCPMC9133764
OpenAlexW4220736375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.