Evidence map›Paper›PMID 35663038›Full record

ArticleiScience2022

Small-molecule fulvic acid with strong hydration ability for non-vitreous cellular cryopreservation.

Guoying Bai, Jinhao Hu, Sijia Qin, Zipeng Qi, Hening Zhuang, Fude Sun, Youhua Lu, Shenglin Jin, Dong Gao, Jianjun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Guoying BaiSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Jinhao HuSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Sijia QinSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Zipeng QiSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Hening ZhuangSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Fude SunKey Laboratory of Hebei Province for Molecular Biophysics Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.
Youhua LuInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Shenglin JinInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Dong GaoKey Laboratory of Hebei Province for Molecular Biophysics Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.
Jianjun WangInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Hebei University of Technology · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exploitation of biocompatible ice-control materials especially the small molecules for non-vitreous cryopreservation remains challenging. Here, we report a small molecule of fulvic acid (FA) with strong hydration ability, which enables non-vitreous cellular cryopreservation by reducing ice growth during freezing and reducing ice recrystallization/promoting ice melting during thawing. Without adding any other cryoprotectants, FA can enhance the recovery of sheep red blood cells (RBCs) by three times as compared with a commercial cryoprotectant (hydroxyethyl starch) under a stringent test condition. Investigation of water mobility reveals that the ice-control properties of FA can be ascribed to its strong bondage to water molecules. Furthermore, we found that FA can be absorbed by RBCs and mainly locates on membranes, suggesting the possible contribution of FA to cell protection through stabilizing membranes. This work bespeaks a bright future for small-molecule cryoprotectants in non-vitreous cryopreservation application.

Indexed as

BiotechnologyChemistryOrganic chemistry

Identifiers

PMID35663038
PMCPMC9157229
OpenAlexW4280547569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.