ArticleiScience2022
Neural activation associated with outgroup helping in adolescent rats.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neural correlates of adversity-overcoming pup rescue behavior in female mice.Scientific reports · 2026Article
- The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Distinct oxytocin populations support seismic social communication and militant behaviors in a naturally solitary wild rodent.iScience · 2025Article
- Mapping brain-wide activity networks: brainways as a tool for neurobiological discovery.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Neural and Behavioral Correlates of Individual Variability in Rat Helping Behavior: A Role for Social Affiliation and Oxytocin Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- The Effect of Temporary Group Identity on Adolescent Social Mindfulness Decisions: An Empirical Study Using Team Sports Contexts.Behavioral sciences (Basel, Switzerland) · 2024Article
- Acute Observational Stimulus of Restrained Mice Induced Anxiolytic Effects in Observer Mice.Neuroscience bulletin · 2024Article
- In search of prosociality in rodents: A scoping review.PloS one · 2024Article
- Assessment of help value affects reciprocation in Norway rats.Royal Society open science · 2023Article
- Why help others? Insights from rodent to human early childhood research.Frontiers in behavioral neuroscience · 2023Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one's own group members or ingroup. To investigate the development of ingroup bias, neural activity during a helping test was analyzed in adolescent and adult rats. Although adults selectively released trapped ingroup members, adolescent rats helped both ingroup and outgroup members, suggesting that ingroup bias emerges in adulthood. Analysis of brain-wide neural activity, indexed by expression of the early-immediate gene c-Fos, revealed increased activity for ingroup members across a broad set of regions previously associated with empathy. Adolescents showed reduced hippocampal and insular activity and increased orbitofrontal cortex activity compared to adults. Non-helper adolescents demonstrated increased amygdala connectivity. These findings demonstrate that biases for group-dependent prosocial behavior develop with age in rats and suggest that specific brain regions contribute to prosocial selectivity, pointing to possible targets for the functional modulation of ingroup bias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.