ArticleiScience2022
Natural VTA activity during NREM sleep influences future exploratory behavior.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Replay of procedural memory is independent of the hippocampus.Nature neuroscience · 2026Article
- VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation.Science advances · 2025Article
- Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals.Nature communications · 2025Article
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
- Wireless monitoring of respiration with EEG reveals relationships between respiration, behavior, and brain activity in freely moving mice.Journal of neurophysiology · 2024Article
- Sleep condition detection and assessment with optical fiber interferometer based on machine learning.iScience · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
During wakefulness, the VTA represents the valence of experiences and mediates affective response to the outside world. Recent work revealed that two major VTA populations - dopamine and GABA neurons - are highly active during REM sleep and less active during NREM sleep. Using long-term cell type and brain state-specific recordings, machine learning, and optogenetics, we examined the role that the sleep-activity of these neurons plays in subsequent awake behavior. We found that VTA activity during NREM (but not REM) sleep correlated with exploratory features of the next day's behavior. Disrupting natural VTA activity during NREM (but not REM) sleep reduced future tendency to explore and increased preferences for familiarity and goal-directed actions, with no direct effect on learning or memory. Our data suggest that, during deep sleep, VTA neurons engage in offline processing, consolidating not memories but affective responses to remembered environments, shaping the way that animals respond to future experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.